Results 41 to 50 of about 1,158,587 (297)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Development and tuning framework of master/worker applications
Journal of Computer Science and Technology, 2005 Parallel/distributed programming is a complex task that requires a high degree of expertise to fulfill the expectations of high performance computation.
Anna Morajko +7 more
doaj
Компютерні системи та інформаційні технології, 2022 mandatory step, which is carried out to confirm the correctness, feasibility and feasibility of the developed solutions, including architecture, method of maintaining system integrity.
BOHDAN SAVENKO, ANTONINA KASHTALIAN
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Fetch unit design for scalable simultaneous multithreading (ScSMT)
Journal of Computer Science and Technology, 2001 Continuous IC process enhancements make possible to integrate on a single chip the re-sources required for simultaneously executing multiple control flows or threads, exploiting different levels of thread-level parallelism: application-, function-, and ...
Juan Carlos Moure +2 more
doaj
Cloud computing application model for online recommendation through fuzzy logic system
Journal of Computer Science and Technology, 2018 Cloud computing can offer us different distance services over the internet. We propose an online application model for using health care systems that works by using cloud computing. It can provide a higher quality of services remotely and along with that,
Emilio Luque +3 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source