Results 121 to 130 of about 770,880 (300)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Match-Unity: Long-Form Text Matching With Knowledge Complementarity

IEEE Access
Semantic text matching is a fundamental task in Natural Language Processing, with existing methods mainly focusing on short texts. However, handling long texts remains a challenge, as conventional approaches often involve slicing or keyword filtering ...
Zhiyi He, Ke Chen, Siyuan Ren, Xinyang He, Xu Liu, Jiakang Sun, Cheng Peng   +6 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Immersive and perceptual human-computer interaction using computer vision techniques

, 2010
Computer vision techniques have been widely applied to immersive and perceptual human-computer interaction for applications like computer gaming, education, and entertainment.
Theodore Vlachos, Vasileios Argyriou, Jinchang Ren, Argyriou, V., Ren, Jinchang, Vlachos, T.   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Carbon calculators as a tool for a low-carbon everyday life?

Sustainability: Science, Practice, & Policy, 2012
The number of Internet-based carbon calculators that estimate personal carbon footprints has been growing in recent years. This article discusses the roles that these calculators can play in changing everyday practices and how users evaluate them.
Kirsten Gram-Hanssen, Toke Haunstrup Christensen   +1 more
doaj  

STGAN: Swin Transformer-Based GAN to Achieve Remote Sensing Image Super-Resolution Reconstruction

Applied Sciences
Super-resolution (SR) of remote sensing images is essential to compensate for missing information in the original high-resolution (HR) images. Single-image super-resolution (SISR) technique aims to recover high-resolution images from low-resolution (LR ...
Wei Huo, Xiaodan Zhang, Shaojie You, Yongkun Zhang, Qiyuan Zhang, Naihao Hu   +5 more
doaj   +1 more source

Symbolic computation: systems and applications

Nonlinear Analysis: Modelling and Control, 1998
The article presents an overview of symbolic computation systems, their classification-in-history, the most popular CAS, examples of systems and some of their applications. Symbolics versus numeric, enhancement in mathematics, computing nature of CAS, related projects, networks, references are discussed.
openaire   +3 more sources