Results 81 to 90 of about 770,880 (300)

Budget constrained execution of multiple Bag-of-Tasks applications on the Cloud

open access: yes, 2015
This research is supported by the EPSRC grant ‘Working Together: Constraint Programming and Cloud Computing’ (EP/K015745/1), a Royal Society Industry Fellowship ‘Bringing Science to the Cloud’, an EPSRC Impact Acceleration Grant (IAA) and an Amazon Web ...
Barker, Adam David   +5 more
core   +1 more source

Investigating computer-supported cooperative learning: applications for flexible learning environments [PDF]

open access: yes, 2005
The key findings of investigations concerned with e-learning computer systems and the establishment of a technology framework for a new generation of applications are described.
Mimirinis, M.   +13 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Computer Aided Verification

open access: yes
This open access 4-volume set constitutes the proceedings of the 37th International Conference on Computer Aided Verification, CAV 2025, held in Zagreb, Croatia, in July 23-25, 2025.

core   +4 more sources

09471 Abstracts Collection – Computer-assisted proofs - tools, methods and applications [PDF]

open access: yes, 2010
From 15.11. to 20.11.2009, the Dagstuhl Seminar 09471 ``Computer-assisted proofs - tools, methods and applications '' was held in Schloss Dagstuhl~--~Leibniz Center for Informatics.
Rump, Siegfried M.   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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