Results 101 to 110 of about 5,552,920 (364)

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Architecture of Computational Ecosystems

open access: yes, 2022
Industry 4.0 ha transformado rápida y significativamente la industria AEC a nivel mundial desde principios de la década de 2000. La profesión profesional de la arquitectura alográfica hasta finales de la década de 1990 ha visto un cambio de paradigma hacia una práctica más autográfica después de la inclusión del algoritmo en el desarrollo ...
openaire   +1 more source

A Computational Study of Tree Architecture [PDF]

open access: yes, 2013
Since their inception in the 1970s, architectural tree models (Hallé et al. 1978) have provided the dominant framework for describing tree forms. An architectural tree model is viewed as a “genetic blueprint” of tree development: a precise developmental pattern subject to disruptive modifications by the environment (Hallé et al. 1978, p.
openaire   +2 more sources

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

open access: yesFEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper   +5 more
wiley   +1 more source

The flight telerobotic servicer: From functional architecture to computer architecture [PDF]

open access: yes
After a brief tutorial on the NASA/National Bureau of Standards Standard Reference Model for Telerobot Control System Architecture (NASREM) functional architecture, the approach to its implementation is shown.
Fiala, John, Lumia, Ronald
core   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

open access: yesFEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić   +3 more
wiley   +1 more source

A computer architecture for intelligent machines [PDF]

open access: yes
The Theory of Intelligent Machines proposes a hierarchical organization for the functions of an autonomous robot based on the Principle of Increasing Precision With Decreasing Intelligence.
Lefebvre, D. R., Saridis, G. N.
core   +1 more source

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao   +34 more
wiley   +1 more source

Special purpose parallel computer architecture for real-time control and simulation in robotic applications [PDF]

open access: yes, 1993
This is a real-time robotic controller and simulator which is a MIMD-SIMD parallel architecture for interfacing with an external host computer and providing a high degree of parallelism in computations for robotic control and simulation.
Bejczy, Antal K., Fijany, Amir
core   +1 more source

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