Results 31 to 40 of about 1,373,407 (260)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Form and Data - from linear Calculus to cybernetic Computation and Interaction [PDF]

, 2019
Digital architecture developed in the 1960s and, supported by CAAD the 1990s, has created the path towards an architecture produced by computer and architect in a mutual relationship.
Werner, Liss C.
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Comparative Analysis of Digital Contact-Tracing Technologies for Informing Public Health Policies

Engineering Proceedings, 2023
Contact tracing is the cornerstone of epidemic control of infectious diseases, especially in the era of COVID-19. This labor-intensive task calls for the use of digital technology to help identify individuals who have potentially been exposed to the ...
Tsz Ho Kwan
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The Role of the Supercomputer in the Modern World of Innovative Technologies

Кібернетика та комп'ютерні технології
What is a supercomputer and why is it needed? What place does it occupy among computing equipment? Thanks to this article, we will determine the evolution and role of the supercomputer in the modern world and in the life of an average citizen.
Nataliia Kravchenko, Andriі Golovynskyi, Andriі Grabowski, Andriі Malenko   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

ALCEA: The Architecture Life-Cycle Effect Analysis Method

IEEE Open Journal of Systems Engineering
This article describes the architecture life cycle effect analysis (ALCEA) method, a structured method for evaluating proposed new architectures for software-intensive systems. The method evaluates a proposed architecture by quantifying its effect on the
Jakob Axelsson, Damir Bilic, Daniel Brahneborg, Joakim Froberg, Henrik Gustavsson, Robbert Jongeling, Daniel Sundmark   +6 more
doaj   +1 more source

An Area Efficient Composed CORDIC Architecture

Advances in Electrical and Computer Engineering, 2014
This article presents a composed architecture for the CORDIC algorithm. CORDIC is a widely used technique to calculate basic trigonometric functions using only additions and shifts.
AGUIRRE-RAMOS, F., MORALES-REYES, A., CUMPLIDO, R., FEREGRINO-URIBE, C.   +3 more
doaj   +1 more source