Results 41 to 50 of about 4,598,340 (299)

A simulated system for teaching computer architecture

open access: yes, 1995
The evolution of computers has led to the current generation of powerful, RISC-based workstations. These systems are often rich of interesting architectural features and peripheral devices.
CORSINI P, RIZZO, LUIGI
core   +1 more source

Simulators for Processors Used in Virtualization: A Survey

open access: yesIEEE Open Journal of the Computer Society
Simulation imitates the modeled system to the desired level of details in the desired time. Cloud computing shares the resources, and virtualization is the key technology that enables cloud computing.
Swapneel C. Mhatre, Priya Chandran
doaj   +1 more source

Fast Hybrid Data Structure for a Large Alphabet K-Mers Indexing for Whole Genome Alignment

open access: yesIEEE Access, 2021
The most common index data structures used by whole genome aligners (WGA) are based on suffix trees (ST), suffix arrays, and FM-indexes. These data structures show good performance results as WGA works with sequences of letters over small alphabets; for ...
Rostislav Hrivnak   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The Role of the Supercomputer in the Modern World of Innovative Technologies

open access: yesКібернетика та комп'ютерні технології
What is a supercomputer and why is it needed? What place does it occupy among computing equipment? Thanks to this article, we will determine the evolution and role of the supercomputer in the modern world and in the life of an average citizen.
Nataliia Kravchenko   +3 more
doaj   +1 more source

Comparative Analysis of Digital Contact-Tracing Technologies for Informing Public Health Policies

open access: yesEngineering Proceedings, 2023
Contact tracing is the cornerstone of epidemic control of infectious diseases, especially in the era of COVID-19. This labor-intensive task calls for the use of digital technology to help identify individuals who have potentially been exposed to the ...
Tsz Ho Kwan
doaj   +1 more source

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