Results 31 to 40 of about 300,740 (315)
Fast Hybrid Data Structure for a Large Alphabet K-Mers Indexing for Whole Genome Alignment
IEEE Access, 2021 The most common index data structures used by whole genome aligners (WGA) are based on suffix trees (ST), suffix arrays, and FM-indexes. These data structures show good performance results as WGA works with sequences of letters over small alphabets; for ...
Rostislav Hrivnak +2 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Tools and Algorithms for the Construction and Analysis of Systems: 24th International Conference, TACAS 2018, Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2018, Thessaloniki, Greece, April 14-20, 2018, Proceedings, Part II [PDF]
, 2018 computer architecture; computer software selection and evaluation; formal logic; formal methods; model checker; model checking; multi core processors; program compilers; programming languages; semantics; software engineering; specifications ...
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Role of the Supercomputer in the Modern World of Innovative Technologies
Кібернетика та комп'ютерні технологіїWhat is a supercomputer and why is it needed? What place does it occupy among computing equipment? Thanks to this article, we will determine the evolution and role of the supercomputer in the modern world and in the life of an average citizen.
Nataliia Kravchenko +3 more
doaj +1 more source
Comparative Analysis of Digital Contact-Tracing Technologies for Informing Public Health Policies
Engineering Proceedings, 2023 Contact tracing is the cornerstone of epidemic control of infectious diseases, especially in the era of COVID-19. This labor-intensive task calls for the use of digital technology to help identify individuals who have potentially been exposed to the ...
Tsz Ho Kwan
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
ALCEA: The Architecture Life-Cycle Effect Analysis Method
IEEE Open Journal of Systems EngineeringThis article describes the architecture life cycle effect analysis (ALCEA) method, a structured method for evaluating proposed new architectures for software-intensive systems. The method evaluates a proposed architecture by quantifying its effect on the
Jakob Axelsson +6 more
doaj +1 more source