Results 61 to 70 of about 1,969,838 (357)

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

open access: yesFEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez   +3 more
wiley   +1 more source

Interconnection Networks for Scalable Quantum Computers [PDF]

open access: yes, 2006
We show that the problem of communication in a quantum computer reduces to constructing reliable quantum channels by distributing high-fidelity EPR pairs. We develop analytical models of the latency, bandwidth, error rate and resource utilization of such
Isailovic, Nemanja   +3 more
core   +3 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

open access: yesFEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner   +7 more
wiley   +1 more source

A Study of Basic 3D Visualization Architecture for Network Operation and Management Tools [PDF]

open access: yes, 2018
Recently, network operation tools using 3D visualization technologies have become more and more important. Generally, 3D visualized network operation tools are useful for computer network management or operation.
Ogashiwa, Nobuo
core  

BRISC-V emulator: a standalone, installation-free, browser-based teaching tool [PDF]

open access: yes, 2020
Many computer organization and computer architecture classes have recently started adopting the RISC-V architecture as an alternative to proprietary RISC ISAs and architectures.
Isakov, Mihailo, Kinsy, Michel A.
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

An Area Efficient Composed CORDIC Architecture

open access: yesAdvances in Electrical and Computer Engineering, 2014
This article presents a composed architecture for the CORDIC algorithm. CORDIC is a widely used technique to calculate basic trigonometric functions using only additions and shifts.
AGUIRRE-RAMOS, F.   +3 more
doaj   +1 more source

Techniques for improving reliability of computers [PDF]

open access: yes, 1972
Modular design techniques improve methods of error detection, diagnosis, and recovery. Theoretical computer (MARCS (Modular Architecture for Reliable Computer Systems)) study deals with postulated and modeled technology indigenous to 1975-1980.
Bouricius, W. G.   +5 more
core   +1 more source

Neural Networks Architecture Evaluation in a Quantum Computer

open access: yes, 2017
In this work, we propose a quantum algorithm to evaluate neural networks architectures named Quantum Neural Network Architecture Evaluation (QNNAE). The proposed algorithm is based on a quantum associative memory and the learning algorithm for artificial
da Silva, Adenilton José   +1 more
core   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

open access: yesMolecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad   +13 more
wiley   +1 more source

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