Results 61 to 70 of about 1,374,683 (343)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Computer-Aided Diagnosis with Deep Learning Architecture: Applications to Breast Lesions in US Images and Pulmonary Nodules in CT Scans

open access: yesScientific Reports, 2016
This paper performs a comprehensive study on the deep-learning-based computer-aided diagnosis (CADx) for the differential diagnosis of benign and malignant nodules/lesions by avoiding the potential errors caused by inaccurate image processing results (e ...
Jie-Zhi Cheng   +8 more
semanticscholar   +1 more source

A Detailed Study of SOT-MRAM as an Alternative to DRAM Primary Memory in Multi-Core Environment

open access: yesIEEE Access
As the current primary memory technology is reaching its limits, it is essential to explore alternative memory technologies to accommodate modern applications and use cases.
H. D. Kallinatha   +2 more
doaj   +1 more source

Computer Analysis of Architecture Using Automatic Image Understanding

open access: yes, 2019
In the past few years, computer vision and pattern recognition systems have been becoming increasingly more powerful, expanding the range of automatic tasks enabled by machine vision.
Li, Yuan, Shamir, Lior, Wei, Fan
core   +1 more source

Generic system architecture for context-aware, distributed recommendation [PDF]

open access: yes, 2017
In the existing literature on recommender systems, it is difficult to find an architecture for large-scale implementation. Often, the architectures proposed in papers are specific to an algorithm implementation or a domain.
Shah, Neel Harish
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The architecture of the spherical sky building and its protective role for the Earth Mechanisms for maintaining the hermetic ceiling - the sky - in architecture

open access: yesJournal of Architecture, Art & Humanistic Science
The sky constitutes an incubating element for the planet Earth that protects it from all the dangers that occur in cosmic space. It can be likened to an outer shell that surrounds the Earth, and it serves as a large envelope or protective ceiling for ...
Dr. Manal Ibrahim Adham Haj Yousef Lecturer at Architecture Department Theba Maadi Academy for Engineering and Computer Science
doaj   +1 more source

Formulation and Implementation of Frequency-Dependent Linear Response Properties with Relativistic Coupled Cluster Theory for GPU-accelerated Computer Architectures [PDF]

open access: green, 2023
Xiang Yuan   +6 more
openalex   +1 more source

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