Results 61 to 70 of about 4,534,399 (284)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Improving the Delay of Residue-to-Binary Converter for a Four-Moduli Set
Advances in Electrical and Computer Engineering, 2011 The residue number system (RNS) is an unconventional number system which can be used to achieve high-performance hardware implementations of special-purpose computation systems such as digital signal processors.
MOLAHOSSEINI, A. S.
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
ALCEA: The Architecture Life-Cycle Effect Analysis Method
IEEE Open Journal of Systems EngineeringThis article describes the architecture life cycle effect analysis (ALCEA) method, a structured method for evaluating proposed new architectures for software-intensive systems. The method evaluates a proposed architecture by quantifying its effect on the
Jakob Axelsson +6 more
doaj +1 more source
Sensors, 2018 In the Republic of Korea, one of the most widely discussed subjects related to future logistics technology is the drone-based delivery (transportation) system. Much (around 75%) of Korea’s territory consists of mountainous areas; however, the costs
Jun-Ho Huh
doaj +1 more source
RASP ABSTRACT MACHINE EMULATOR – EXTENDING THE EMUSTUDIO PLATFORM [PDF]
Acta Electrotechnica et Informatica, 2017 This paper presents the RASP (Random Access Stored Program) abstract machine emulator implemented as a plugin for emuStudio – extendable platform for computer architectures emulation.
Michal ŠIPOŠ, Slavomír ŠIMOŇÁK
doaj +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Development Status and Trends of Space Processor
天地一体化信息网络, 2023 Space electronic system is the ＆quot;brain＆quot; of aerospace engineering models and the core fi eld of competitive development of major countries around the world.As the most core device in space electronic system, space processor directly aff ects the ...
Zhigang YU +4 more
doaj