Results 61 to 70 of about 9,040,290 (284)
Interaction Design and Architecture(s)Creativity support tools (CSTs) play a fundamental role in supporting creativity in human-computer interaction (HCI). The rapid development of artificial intelligence (AI), particularly Large Language Models (LLMs), has significantly transformed ...
Ana Rodrigues +3 more
doaj +1 more source
Evolution and innovation in guardianship laws: Assisted decision-making [PDF]
, 2013 Guardianship laws in most Western societies provide decision-making mechanisms for adults with impaired capacity. Since the inception of these laws, the principle of autonomy and recognition of human rights for those coming within guardianship regimes ...
Then, Shih-Ning
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Decision Making: A Computer-Science and Information-Technology Viewpoint [PDF]
We address the phenomenon of decision making from the viewpoint of computer science and information technology. The basic question from this viewpoint is: what can the computer offer to decision makers and how it can support their work?
Marko Bohanec
core
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Accuracy of automated analysis in cephalometry
Journal of Dental SciencesBackground/purpose: Artificial intelligence (AI) has been widely used in medicine, including orthodontics. The aim of this study was to investigate the training process of a cascaded Convolutional Neural Network (CNN), built for landmark detection on ...
Réka Bagdy-Bálint +6 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The preconditions for computer-assisted decision-making in tomorrow’s schools [PDF]
, 1997 This paper is a summary of a multi-session group discussion among the listed authors in which they deal with three broad questions: What sorts of decisions need to be made in schools? What kinds of computer assistance would be helpful? What are the barriers to obtaining this assistance?
P. Hogenbirk +4 more
openaire +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source