Results 61 to 70 of about 18,294 (257)

Aplikasi Perangkat Ajar “Petualangan Fisika” Berbasis Multimedia untuk SMP Kelas 8

ComTech, 2011
Multimedia can be used as a supportive element in education. The most significant implementation of multimedia is shown in computer assisted instruction (CAI).
Fredy Purnomo, Silviana Simidjaja, Dwi Pangestuti, Anggondo Paulus Stifanus   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Angiographic Anatomy of the Upper and Lower Extremities

MedEdPORTAL, 2012
This interactive tutorial serves as an introduction to normal vascular anatomy of the extremities for preclinical medical students. It is composed of high-quality digital subtraction angiography and surface-rendered CT images containing comprehensive ...
Frank D. Reilly, Robert J. Tallaksen, Patricia B. Stoltzfus, Daniel E. Sloan, Penprapa Klinkhachorn, Frank A. Hamilton, Powsiri Klinkhachorn   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pediatric Call

MedEdPORTAL, 2007
Introduction This is an interactive module tool for third-year medical students rotating through Pediatrics. The objective of this tool is to allow students to experience clinical situations that are required but which may not be available during the ...
Benjamin Estrada
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Upper Limbs Interactive Learning Objects (Out of Print)

MedEdPORTAL, 2010
Introduction This is a collection of 86 self-test exercises related to upper limb anatomy including, upper arm, upper back, cubital fossa, forearm, hand, rotator cuff, and scapular-humeral mechanism.
Elizabeth Walker, Edwin Allen, Barbara Kraszpulska, Heather Billings   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PENGEMBANGANMODELREMEDI MATEMATIKASMA BERBANTUANKOMPUTER.

Cakrawala Pendidikan: Jurnal Ilmiah Pendidikan, 2005
This article is about a research conducted to design and implement the development of a software model for a program of computer-assisted instruction (CAl) used to remedy senior high school students' achievement in learning mathematics (especially in the
Boko Susilo
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source