Results 41 to 50 of about 28,205 (240)

A comparative study of the electrochemical properties of vitamin B-6 related compounds at physiological pH [PDF]

, 2011
A comparative study of vitamin B6 group and related compounds in buffered solutions using electrochemical techniques has been performed at neutral pH.
A. Pocker, A. Temizer, A.E. Braunstein, A.J. Bard, A.J. Román, A.K. Lunn, C.M. Harris, C.M. Metzler, D. Manousek, E.E. Snell, H. Lund, J. Gonzalez-Rodríguez, J. Llor, J. Llor, J. M. Sevilla, J.M. Rodríguez Mellado, J.M. RodrÍguez Mellado, J.M. RodrÍguez Mellado, J.M. RodrÍguez Mellado, L. Camacho, M. Blázquez, M. Blázquez, M. Heyrovský, M. Stanulovic, M.L. Ahrens, M.S. Ibrahim, N.P. Bazhulina, P. Zuman, P. Zuman, R. Izquierdo, R. Izquierdo, R. Schwartz, S.G. Mairanoskii, T. Pineda, T. Pineda, T. Pineda, V. Mirceski, W.F. Wolkers, Y.V. Morozov   +38 more
core   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Natural product-likeness score revisited: an open-source, open-data implementation

BMC Bioinformatics, 2012
Background Natural product-likeness of a molecule, i.e. similarity of this molecule to the structure space covered by natural products, is a useful criterion in screening compound libraries and in designing new lead compounds.
Jayaseelan Kalai Vanii, Moreno Pablo, Truszkowski Andreas, Ertl Peter, Steinbeck Christoph   +4 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Spin Hamiltonian Parameters for Cu(II)−Prion Peptide Complexes from L-Band Electron Paramagnetic Resonance Spectroscopy [PDF]

, 2011
Cu(II) is an essential element for life but is also associated with numerous and serious medical conditions, particularly neurodegeneration. Structural modeling of crystallization-resistant biological Cu(II) species relies on detailed spectroscopic ...
Bennett, Brian, Kowalski, Jason M.
core   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]

, 2005
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo, Azam, Baker, Balestra, Bleckmann, Bobbin, Boulter, Cartier, Champtiaux, Chernyavsky, Colquhoun, Conroy, Couturier, Dawkins, Deneris, Drescher, Duvoisin, Elgoyhen, Elgoyhen, Engelmann, Flock, Fuchs, Genzen, Gerzanich, Gerzanich, Glowatzki, Goldman, Gotti, Gotti, Groot-Kormelink, Guinan, Haberberger, Jones, Karlin, Katz, Katz, Kros, Kurzen, Le Novere, Lips, Luebke, Lustig, McIntosh, McIntosh, Mihovilovic, Morley, Nguyen, Nicke, Peng, Pohlmann, Rothlin, Russell, Santos, Sato, Seguela, Sgard, Terlau, Walker, Wals, Weisstaub   +59 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Lectin ligands: New insights into their conformations and their dynamic behavior and the discovery of conformer selection by lectins [PDF]

, 1998
The mysteries of the functions of complex glycoconjugates have enthralled scientists over decades. Theoretical considerations have ascribed an enormous capacity to store information to oligosaccharides, In the interplay with lectins sugar-code words of ...
Bovin, N. V., Burchert, M., Frank, M., Gabius, Hans-Joachim, Gilleron, M., Kaltner, Herbert, Kayser, G., Kozár, T., Lieth, Claus-Wilhelm von der, Siebert, H. C., Tajkhorshid, Emad, Vliegenthart, JFG   +11 more
core   +4 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source