Results 61 to 70 of about 4,050 (238)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Reconhecimento de padrões em moléculas orgânicas de origem vegetal em um banco de estruturas tridimensionais [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Ciência da ComputaçãoAtravés da técnica de Morgan-Gastmans, combinada com a de Sippl-Stegbuchner, fazendo uso de recursos de IA e de lógica ...
Martinovsky, Iêdo Luiz
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Penicitone: Structural Reassignment of a Proposed Natural Product Acid Chloride

, 2023
The proposed structure for the natural product penicitone, which contained a chemically improbable acid chloride functional group, was reassigned to a more probable structure using a combination of chemical knowledge, computer-assisted structure ...
Mikhail Elyashberg, Andrei G. Kutateladze (1344246), Craig M. Williams, Ivan M. Novitskiy (2122903), Andrei G. Kutateladze, Roderick W. Bates (2175544), Roderick W. Bates, Craig M. Williams (1939036), Ivan M. Novitskiy, Mikhail Elyashberg (390093)   +9 more
core   +1 more source

3-D Structural Modeling of Humic Acids through Experimental Characterization, Computer Assisted Structure Elucidation and Atomistic Simulations. 1. Chelsea Soil Humic Acid [PDF]

, 2003
This paper describes an integrated experimental and computational framework for developing 3-D structural models for humic acids (HAs). This approach combines experimental characterization, computer assisted structure elucidation (CASE), and atomistic ...
Johnson, James H., Jr., Hatcher, Patrick G., Faulon, Jean Loup, Diallo, Mamadou S., Simpson, Andre, Gassman, Paul, Goddard, William A., III   +6 more
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Investigation of phytochemical profiling and biological activities of methanol extract from Eryngium billardieri: antimicrobial, antibiofilm, and anthelmintic properties

Frontiers in Plant Science
The genus Eryngium, belonging to the Umbelliferae family, comprises flowering plants with various pharmacological activities, including anti-inflammatory and antidiabetic properties. However, many of these activities lack scientific evaluation.
Mahdi Yaghoobi, Mahdi Yaghoobi, Mahdi Moridi Farimani, Ajmal Khan, Ajmal Khan, Mojtaba Asadollahi, Marzieh Omrani, Walter Luyten, Haibo Hu, Haibo Hu   +9 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Computer-assisted structure elucidation: application of CISOC-SES to the resonance assignment and structure generation of betulinic acid

The application of a computer-assisted structure elucidation expert system, CISOC-SES, leading to the unequivocal 1H, 13C and NOE resonance assignment of betulinic acid, a biol. active triterpenoid with complicated NMR resonances, is described.
Fong, Harry H. S., Qiu, Shengxiang, Bodenhausen, Geoffrey, Farnsworth, Norman R., Zheng, Chongzhi, Peng, Chen, Yuan, Shengang   +6 more
core   +1 more source