Results 51 to 60 of about 27,265 (258)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Finding Characteristic Substructures for Metabolite Classes [PDF]

, 2012
We introduce a method for finding a characteristic substructure for a set of molecular structures. Different from common approaches, such as computing the maximum common subgraph, the resulting substructure does not have to be contained in its exact form
Böcker, S., Elshamy, S., Hufsky, F., Ludwig, M.   +3 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

EUROCarbDB: An open-access platform for glycoinformatics [PDF]

, 2017
The EUROCarbDB project is a design study for a technical framework, which provides sophisticated, freely accessible, open-source informatics tools and databases to support glycobiology and glycomic research. EUROCarbDB is a relational database containing
Blank, Dennis, Campbell, Matthew P., Ceroni, Alessio, Damerell, David R., Dell, Anne, Dwek, Raymond A., Ernst, Beat, Fogh, Rasmus, Frank, Martin, Freire, Ana Ardá, Geyer, Hildegard, Geyer, Rudolf, Harrison, Mathew J., Haslam, Stuart M., Henrick, Kim, Herget, Stefan, Hull, William E., Ionides, John, Joshi, Hiren J., Kamerling, Johannis P., Leeflang, Bas R., Lundborg, Magnus, Lütteke, Thomas, Maass, Kai, Merry, Anthony, Ranzinger, René, Rosen, Jimmy, Royle, Louise, Rudd, Pauline M., Schloissnig, Siegfried, Stenutz, Roland, von der Lieth, Claus-Wilhelm, Vranken, Wim F., Widmalm, Göran   +33 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Recovery of the procedure of combined handling of elucidation methods for interpretable structure elucidation for decreasing frequencies of organic structure revision [PDF]

, 2006
Maybe more than one hundred papers on revision of organic structure appear every year. Most of them derive from unreasonable neglect of correct structures because of picking-up/angling methodology. Antithetically, the present paper recommends scooping-up/
Kudo Yoshihiro, Sato Noriko
core   +1 more source

Ultralow-frequency collective compression mode and strong interlayer coupling in multilayer black phosphorus

, 2015
The recent renaissance of black phosphorus (BP) as a two-dimensional 2D layered material has generated tremendous interest in its tunable electronic band gap and highly anisotropic transport properties that offer new opportunities for device applications.
Chen, Changfeng, Chen, X. H., Dong, Shan, Ji, Jianting, Jie, Yinghao, Liu, Kai, Luo, X. G., Ma, Xiaoli, Wang, Xiaoqun, Ye, Y. G., Zhang, Anmin, Zhang, Qingming   +11 more
core   +1 more source

Affective Medicine: a review of Affective Computing efforts in Medical Informatics [PDF]

, 2010
Background: Affective computing (AC) is concerned with emotional interactions performed with and through computers. It is defined as “computing that relates to, arises from, or deliberately influences emotions”. AC enables investigation and understanding
Bamidis, Panagiotis, Konstantinidis, Evdokimos, Luneski, Andrej   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source