Results 51 to 60 of about 28,205 (240)

Finding Characteristic Substructures for Metabolite Classes [PDF]

, 2012
We introduce a method for finding a characteristic substructure for a set of molecular structures. Different from common approaches, such as computing the maximum common subgraph, the resulting substructure does not have to be contained in its exact form
Böcker, S., Elshamy, S., Hufsky, F., Ludwig, M.   +3 more
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

EUROCarbDB: An open-access platform for glycoinformatics [PDF]

, 2017
The EUROCarbDB project is a design study for a technical framework, which provides sophisticated, freely accessible, open-source informatics tools and databases to support glycobiology and glycomic research. EUROCarbDB is a relational database containing
Blank, Dennis, Campbell, Matthew P., Ceroni, Alessio, Damerell, David R., Dell, Anne, Dwek, Raymond A., Ernst, Beat, Fogh, Rasmus, Frank, Martin, Freire, Ana Ardá, Geyer, Hildegard, Geyer, Rudolf, Harrison, Mathew J., Haslam, Stuart M., Henrick, Kim, Herget, Stefan, Hull, William E., Ionides, John, Joshi, Hiren J., Kamerling, Johannis P., Leeflang, Bas R., Lundborg, Magnus, Lütteke, Thomas, Maass, Kai, Merry, Anthony, Ranzinger, René, Rosen, Jimmy, Royle, Louise, Rudd, Pauline M., Schloissnig, Siegfried, Stenutz, Roland, von der Lieth, Claus-Wilhelm, Vranken, Wim F., Widmalm, Göran   +33 more
core  

Affective Medicine: a review of Affective Computing efforts in Medical Informatics [PDF]

, 2010
Background: Affective computing (AC) is concerned with emotional interactions performed with and through computers. It is defined as “computing that relates to, arises from, or deliberately influences emotions”. AC enables investigation and understanding
Bamidis, Panagiotis, Konstantinidis, Evdokimos, Luneski, Andrej   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools. [PDF]

, 2016
This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function.
Chang, Chia-En A, Huang, Yu-Ming M, Mueller, Leonard J, You, Wanli   +3 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Recovery of the procedure of combined handling of elucidation methods for interpretable structure elucidation for decreasing frequencies of organic structure revision [PDF]

, 2006
Maybe more than one hundred papers on revision of organic structure appear every year. Most of them derive from unreasonable neglect of correct structures because of picking-up/angling methodology. Antithetically, the present paper recommends scooping-up/
Kudo Yoshihiro, Sato Noriko
core   +1 more source

Ultralow-frequency collective compression mode and strong interlayer coupling in multilayer black phosphorus

, 2015
The recent renaissance of black phosphorus (BP) as a two-dimensional 2D layered material has generated tremendous interest in its tunable electronic band gap and highly anisotropic transport properties that offer new opportunities for device applications.
Chen, Changfeng, Chen, X. H., Dong, Shan, Ji, Jianting, Jie, Yinghao, Liu, Kai, Luo, X. G., Ma, Xiaoli, Wang, Xiaoqun, Ye, Y. G., Zhang, Anmin, Zhang, Qingming   +11 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source