Results 61 to 70 of about 28,205 (240)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Human pol II promoter prediction: time series descriptors and machine learning [PDF]

, 2005
Although several in silico promoter prediction methods have been developed to date, they are still limited in predictive performance. The limitations are due to the challenge of selecting appropriate features of promoters that distinguish them from non ...
Gangal, Rajeev, Sharma, Pankaj
core   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Recent trends and developments in pyrolysis-gas chromatography: review [PDF]

, 2008
Pyrolysis-gas chromatography (Py-GC) has become well established as a simple, quick and reliable analytical technique for a range of applications including the analysis of polymeric materials.
Arias, Armitage, Aslan, Asperger, Asperger, Asperger, Asperger, Bertini, Beyer, Blackledge, Blokker, Bonaduce, Bruck, Buckley, Buco, Campbell, Casas-Catalán, Causin, Challinor, Challinor, Challinor, Chang, Chiavari, Choi, Choi, Colombini, De Koeijer, De la Cruz-Canizares, Dignac, Doménech-Carbó, Doménech-Carbó, Dunn, Dzierzega-Lecznar, Dzierzega-Lecznar, Egan, Erickson, Evans, Evans, Fabbri, Fabbri, Fanter, Fifield, Flodin, Garcette-Lepecq, Gleixner, González-Vila, Goodacre, Greenwood, Greenwood, Greenwood, Greenwood, Guo, Gupta, Göbbels, Gözet, Halket, Halket, Heffenden, Herrera, Horrocks, Ikeya, Ishikawa, Islas, Jakab, Jamin, Jansson, Jarde, Jia, Jin, Jose Gonzalez-Rodriguez, Karina L. Sobeih, Kechang, Kochanowski, Kumooka, Lattimer, Lazaro, Learner, Levy, Li, Ling, Liu, Mao, Marinari, Marinari, Mark Baron, Marques, Maynard, Meruva, Metz, Moldoveanu, Mowry, Munson, Mäkinen, Nierop, Odermatt, Odermatt, Oguz, Ohshima, Osete-Cortina, Osete-Cortina, Osete-Cortina, Park, Parsi, Parsi, Parsi, Parsi, Partouche, Pasch, Peacock, Pel, Pel, Perng, Perng, Petsch, Poerschmann, Poirier, Prasad, Prati, Raghavan, Raulin, Ristau, Ristolainen, Rodriguez, Ross, Räisänen, Sakayanagi, Scalarone, Schmidt, Schwarzinger, Sephton, Sessions, Snyder, Stauffer, Stout, Stout, Stout, Suelves, Sugden, Sun, Sundarrajan, Suuronen, Takayasu, Takayasu, Tanczos, Thomsen, Tsai, Tsuge, Tsuge, Tzamtzis, Urakami, Uyar, Uyar, Vanderborgh, Volkman, Wampler, Wampler, Wampler, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, White, Wilkes, Wilkes, Yamamoto, Yang, Yaylayan, Yinon, Zhang, Zhou, Zhu, Zimmerman, Zlotnick, Çoban-Yildiz, Łakomy   +179 more
core   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Declines in prevalence of adolescent substance use disorders and delinquent behaviors in the USA: A unitary trend? [PDF]

, 2017
BackgroundDownward trends in a number of adolescent risk behaviors including violence, crime, and drug use have been observed in the USA in recent years.
Agrawal, Arpana, Bierut, L. J, Bongu, J., Cavazos-Rehg, P. A, Grucza, R. A, Krauss, M. J, Krueger, R. F, Plunk, A. D   +7 more
core   +2 more sources

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source