Results 51 to 60 of about 1,164,549 (348)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Effect of surface state hybridization on current-induced spin-orbit torque in thin topological insulator films

Scientific Reports, 2017
We investigate the thickness optimization for maximum current-induced spin-orbit torque (SOT) generated by topological surface states (TSS’s) in a bilayer system comprising of a ferromagnetic layer coupled to a thin topological insulator (TI) film.
Cong Son Ho, Yi Wang, Zhou Bin Siu, Seng Ghee Tan, Mansoor B. A. Jalil, Hyunsoo Yang   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Dose-dependent chemotranscriptomics analysis of the differential effects of vitamin D₃ on gene expression in human neuronal progenitor cells NPC and in MCF7 tumor cells

Фармакокинетика и Фармакодинамика, 2018
Resume. Different cell types respond differently to the effects of vitamin D3. The paper presents the results of a dose-dependent differential chemotranscriptome analysis of vitamin D3 in relation to breast tumor cells (MCF7 line) and neuron progenitor ...
I. Yu. Torshin, O. A. Gromova, D. E. Frolova, T. R. Grishina, N. P. Lapochkina   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Ensuring data storage security in Cloud Computing [PDF]

2009 17th International Workshop on Quality of Service, 2009
Cloud Computing has been envisioned as the next-generation architecture of IT Enterprise. In contrast to traditional solutions, where the IT services are under proper physical, logical and personnel controls, Cloud Computing moves the application software and databases to the large data centers, where the management of the data and services may not be ...
null Cong Wang, null Qian Wang, null Kui Ren, null Wenjing Lou   +3 more
openaire   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Hybrid SRRs Design and Fabrication for Broadband Terahertz Metamaterials

IEEE Photonics Journal, 2012
Hybrid metamaterials comprising split-ring resonator (SRR) structures with different gap dimensions are fabricated on polyethylene naphthalate (PEN) films by parallel laser micro-lens array (MLA) lithography and a liftoff process. The unit cell of hybrid
Z. Y. Pan, P. Zhang, Z. C. Chen, G. Vienne, M. H. Hong   +4 more
doaj   +1 more source

DAT for the computer data storage.

The Journal of the Institute of Television Engineers of Japan, 1989
DATは音楽2時間分で1.4Gバイト相当の記憶容量を有している.記録しながらその記録データを読出し確認する機能や, データのランダム書き換え機能, 誤り訂正符号などの追加を行うことができ, コンピュータ用磁気ディスクのバックアップ用や, 衛星画像, 医療用画像などの大量データのファイル用としての応用が拡がろうとしている.
openaire   +2 more sources