Results 101 to 110 of about 2,726,757 (225)

A local area computer network expert system framework [PDF]

open access: yes
Over the past years an expert system called LANES designed to detect and isolate faults in the Goddard-wide Hybrid Local Area Computer Network (LACN) was developed.
Dominy, Robert
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network-based malcode detection technology

open access: yesTongxin xuebao, 2007
Following the analysis for traditional distributed IDS,disadvantages that applying structure of multiple engine and small rules set to detect network-level malcode were pointed out,which is based on detailed protocol decoding.Detection model and anti ...
WU Bing1, YUN Xiao-chun2, GAO Qi1
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Bayesian-network-approximate-reasoning-based method for network vulnerabilities evaluation

open access: yesTongxin xuebao, 2008
To evaluate the large-scale computer networks,a Bayesian-network-approximate-reasoning-based method for vulnerabilities evaluation was proposed.First,it models the elements which compose the network and the factors which affect the network security ...
JIA Wei1   +3 more
doaj  

Development of the analytical model and method of optimization of the priority service corporate computer "Elections" network

open access: yesInformatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
The main objective of this article is to provide recommendations for improving the quality of service indicators in priority service corporate computer networks, including the probability of denial of service attacks, the probability of timely and ...
Zakir Nasib Huseynov
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Queuing system GI/M/1/N with randomly dropping packets mechanism

open access: yesTongxin xuebao, 2006
For the original GI/M/1/N queuing system was not suitable to model the queue management mechanism,a queuing system GI/M/1/N with randomly dropping packets mechanism was discussed by means of thinning of recurrent flows.In addition,the packet loss rate ...
WANG Hao1, LI Xiao-ming1
doaj  

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