Results 61 to 70 of about 2,039,081 (285)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A distributed ledger based platform for community-driven flexibility provision

Energy Informatics, 2019
In this paper we propose and analyze a community-driven platform for flexibility provision based on a distributed ledger. We introduce and analyze the platform for the use case of a self-organized decentralized virtual power plant consisting of a local ...
Jonas Schlund, Reinhard German
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Response of Boolean networks to perturbations

, 2008
We evaluate the probability that a Boolean network returns to an attractor after perturbing h nodes. We find that the return probability as function of h can display a variety of different behaviours, which yields insights into the state-space structure.
Aleksiejuk, B. Drossel, Bassler, C. Fretter, Derrida, Greil, Kauffman, Kauffman, Kaufman, Lagomarsino, Li, McAdams, Moreira, Rosen-Zvi, Shmulevich, Szejka   +15 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

LSTM and ResNet18 for optimized ambulance routing and traffic signal control in emergency situations

Scientific Reports
Traffic congestion, particularly in rapidly expanding urban centers, significantly impacts the timely delivery of emergency medical services (EMS), where every minute can mean the difference between life and death.
Madallah Alruwaili, Ali Ali, Mohammed Almutairi, Abdulaziz Alsahyan, Mahmood Mohamed   +4 more
doaj   +1 more source

Ecological Design of Cooperative Human-Machine Interfaces for Safety of Intelligent Transport Systems

MATEC Web of Conferences, 2016
The paper describes research results in the domain of cooperative intelligent transport systems. The requirements for human-machine interface considering safety issue of for intelligent transport systems (ITS)are analyzed.
Orekhov Aleksandr, Orekhova Anastasiia, Kharchenko Vyacheslav   +2 more
doaj   +1 more source

Multi-Competitive Viruses over Static and Time--Varying Networks

, 2017
Epidemic processes are used commonly for modeling and analysis of biological networks, computer networks, and human contact networks. The idea of competing viruses has been explored recently, motivated by the spread of different ideas along different ...
Başar, Tamer, Beck, Carolyn L., Liu, Ji, Nedić, Angelia, Paré, Philip E.   +4 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source