Results 121 to 130 of about 3,299,091 (308)

Visual device to assist computer program debugging [PDF]

open access: yes, 1970
Interrupt status indicators allow computer programs to be debugged during checkout and provide a quick-look analysis for updating. Computer coupled indicator lamps and lamp driver circuitry register program malfunctions in priority interrupt controlled ...
Garcia, G.
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

General series solution technique for bending of irregular laterally loaded flat plates [PDF]

open access: yes, 1969
Computer program calculates the stresses and lateral deflections to a uniform thickness flat plate with a uniform pressure load. The plate to be analyzed may have several different boundary conditions.
Swanson, J. A.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Expanded sun-look angle program [PDF]

open access: yes, 1970
Computer program provides time history of sun aspect angles as seen from spacecraft and generates binary tape containing time history of position, velocity, and body attitude angles of vehicle in local horizontal, local vertical system.
Boyd, C. C.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

RDP5: a computer program for analyzing recombination in, and removing signals of recombination from, nucleotide sequence datasets. [PDF]

open access: yesVirus Evol, 2021
Martin DP   +8 more
europepmc   +1 more source

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