Results 101 to 110 of about 1,193,637 (279)

A Visual Programming Paradigm for Abstract Deep Learning Model Development

open access: yes, 2019
Deep learning is one of the fastest growing technologies in computer science with a plethora of applications. But this unprecedented growth has so far been limited to the consumption of deep learning experts.
Aralikatte, Rahul   +5 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Final documentation of the LUNAR program and emendations to scientific report no. 9 [PDF]

open access: yes
Computer program checkout programming with complete printout of corrected ...
Newell, J. B.
core   +1 more source

Bringing static code to life: The instructional work of animating computer programs with the body [PDF]

open access: yes, 2018
In this preliminary report, we propose a previously unidentified role that instructors’ gestures may play in helping students evaluate existing computer code. We find that instructors use gesture to animate processes encoded in the static inscriptions of
Abrahamson, D, Deliema, D, Flood, VJ
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

- and -labeling problems on interval graphs

open access: yesAKCE International Journal of Graphs and Combinatorics, 2017
For a given graph , the - and -labeling problems assign the labels to the vertices of . Let be the set of non-negative integers. An - and -labeling of a graph is a function such that , for respectively, where represents the distance (minimum number of ...
Sk Amanathulla, Madhumangal Pal
doaj   +1 more source

Computer assisted modelling of linear, integer and separable programming problems [PDF]

open access: yes, 1984
For mathematical programming (MP) to have greater impact upon the decision making process, MP software systems must offer suitable support in terms of model communication and modelling techniques .
Darby-Dowman, K, Lucas, CA, Mitra, G
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Technique to eliminate computational instability in multibody simulations employing the Lagrange multiplier [PDF]

open access: yes
A programming technique to eliminate computational instability in multibody simulations that use the Lagrange multiplier is presented. The computational instability occurs when the attached bodies drift apart and violate the constraints.
Watts, G.
core   +1 more source

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