Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Cost-benefit considerations have limited effect on the decision to exert cognitive effort in real-world computer-programming tasks. [PDF]
R Soc Open Sci, 2022 Lachman I, Hadar I, Hertz U.
europepmc +1 more source
Optimal Placement of Valves in a Water Distribution Network with CLP(FD)
, 2011 This paper presents a new application of logic programming to a real-life problem in hydraulic engineering. The work is developed as a collaboration of computer scientists and hydraulic engineers, and applies Constraint Logic Programming to solve a hard ...
Alvisi, Stefano +4 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The Scientific World Journal, 2013 Marriage in honey bees optimization (MBO) is a metaheuristic optimization algorithm developed by inspiration of the mating and fertilization process of honey bees and is a kind of swarm intelligence optimizations.
Yuksel Celik, Erkan Ulker
doaj +1 more source
Thinking processes used by high-performing students in a computer programming task
The Journal for Transdisciplinary Research in Southern Africa, 2011 Computer programmers must be able to understand programming source code and write programs that execute complex tasks to solve real-world problems. This article is a trans- disciplinary study at the intersection of computer programming, education and ...
Marietjie Havenga +2 more
doaj +1 more source
Comparing learners' knowledge, behaviors, and attitudes between two instructional modes of computer programming in secondary education. [PDF]
Int J STEM Educ, 2021 Sun D, Ouyang F, Li Y, Zhu C.
europepmc +1 more source
Computer-aided programming for multiprocessing systems [PDF]
, 1988 As both the number of processors and the complexity of problems to be solved increase, programming multiprocessing systems becomes more difficult and error-prone.
Gajski, Daniel D., Wu, Min-You
core
A Purely Functional Computer Algebra System Embedded in Haskell
, 2018 We demonstrate how methods in Functional Programming can be used to implement a computer algebra system. As a proof-of-concept, we present the computational-algebra package.
G-M Greuel +5 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source