Results 71 to 80 of about 10,898,978 (363)
Computer science in K-12 school curricula of the 2lst century: Why, what and when?
Education and Information Technologies : Official Journal of the IFIP technical committee on Education, 2016 In this paper we have examined the position and roles of Computer Science in curricula in the light of recent calls for curriculum change and we have proposed principles and issues to consider in curriculum design as well as identifying priority areas ...
Mary E. Webb +6 more
semanticscholar +1 more source
Infection Models for Pine Wilt Disease on the Basis of Vector Behaviors
Population Ecology, EarlyView.Infection models for pine wilt disease without vector density were built to estimate the transmission coefficient of the pathogenic nematode. The models successfully simulated the annual change in the density of infected trees for four pine stands. ABSTRACT Pine wilt disease is caused by the pinewood nematode (Bursaphelenchus xylophilus Steiner et ...
Katsumi Togashi
wiley +1 more source
Computational Science: An Intermingling of Science, Mathematics, and Computer Science [PDF]
, 2006 The development of a full undergraduate program in computational science, with both a broad-swath academic plan and four specialization plans, one each in biochemistry, chemistry, earth sciences, and physics, is described. The reasons behind the establishment of the program are presented, and the evolution of the program over the past five years is ...
openaire +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Designing Equilibria in Concurrent Games with Social Welfare and Temporal Logic Constraints [PDF]
Logical Methods in Computer ScienceIn game theory, mechanism design is concerned with the design of incentives so that a desired outcome of the game can be achieved. In this paper, we explore the concept of equilibrium design, where incentives are designed to obtain a desirable ...
Julian Gutierrez +3 more
doaj +1 more source
Ubiquity symposium: The science in computer science: unplugging computer science to find the science [PDF]
Ubiquity, 2014 The Computer Science Unplugged project provides activities that enable students to engage with concepts from computer science without having to program. Many of the activities provide the basis of a scientific exploration of computer science, and thus help students to see the relationship of the discipline with science.
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Measure Transformer Semantics for Bayesian Machine Learning [PDF]
Logical Methods in Computer Science, 2013 The Bayesian approach to machine learning amounts to computing posterior distributions of random variables from a probabilistic model of how the variables are related (that is, a prior distribution) and a set of observations of variables.
Johannes Borgström +4 more
doaj +1 more source