Results 31 to 40 of about 2,359,634 (264)

Wolpert, Chaitin and Wittgenstein on impossibility, incompleteness, the liar paradox, theism, the limits of computation, a non-quantum mechanical uncertainty principle and the universe as computer—the ultimate theorem in Turing Machine Theory (revised 2019) [PDF]

, 2019
I have read many recent discussions of the limits of computation and the universe as computer, hoping to find some comments on the amazing work of polymath physicist and decision theorist David Wolpert but have not found a single citation and so I ...
Starks, Michael
core  

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Bringing Computer Science Concepts into the Language Classroom: A Case Study on Teachers’ and Students’ Perception on Modeling to Teach Computational Thinking [PDF]

, 2022
Marina Rottenhofer, Sandra M. Leitner, Lisa Kuka, Bárbara Sabitzer   +3 more
openalex   +1 more source

Towards Human-AI Collaborative Urban Science Research Enabled by Pre-trained Large Language Models [PDF]

arXiv, 2023
Pre-trained large language models (PLMs) have the potential to support urban science research through content creation, information extraction, assisted programming, text classification, and other technical advances. In this research, we explored the opportunities, challenges, and prospects of PLMs in urban science research.
arxiv  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

TEACHING ENGLISH LANGUAGE THROUGH COMPUTER SCIENCE

, 2023
Computer is used in linguistic activity with multiple faces, summarized in three main pictures. Namely: general use, specific use, and specialized linguistic use. This paper tries to highlight the benefits and uses of computers in English Language teaching.
openaire   +2 more sources

Creative Computation for CS1 and K9-12 [PDF]

, 2016
We present the design and development of a new approach to teaching the introductory computing course (CS1), at both the college-level as well as K9-12, using the context of digital art and creative computation.
Greenberg, Ira, Kumar, Deepak, Wolz, Ursula, Xu, Dianna   +3 more
core   +4 more sources

Live Multi-language Development and Runtime Environments [PDF]

The Art, Science, and Engineering of Programming, 2018, Vol. 2, Issue 3, Article 8, 2018
Context: Software development tools should work and behave consistently across different programming languages, so that developers do not have to familiarize themselves with new tooling for new languages. Also, being able to combine multiple programming languages in a program increases reusability, as developers do not have to recreate software ...
arxiv   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source