Results 31 to 40 of about 31,041 (265)

Enhancing Workflow with a Semantic Description of Scientific Intent [PDF]

open access: yes, 2011
Peer ...
Edoardo Pignotti   +7 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Computation of infix probabilities for probabilistic context-free grammars

open access: yes, 2011
The notion of infix probability has been introduced in the literature as a generalization of the notion of prefix (or initial substring) probability, motivated by applications in speech recognition and word error correction.
Satta, Giorgio   +4 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Datalog as a parallel general purpose programming language

open access: yes, 2010
The increasing available parallelism of computers demands new programming languages that make parallel programming dramatically easier and less error prone.
Cleary, John G.   +2 more
core  

KLAIM: A Kernel Language for Agents Interaction and Mobility

open access: yes, 1998
We investigate the issue of designing a kernel programming language for mobile computing and describe KLAIM, a language that supports a programming paradigm where processes, like data, can be moved from one computing environment to another.
Gian Luigi Ferrari   +5 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

A Parallel semantics for normal logic programs plus time

open access: yes, 2013
It is proposed that Normal Logic Programs with an explicit time ordering are a suitable basis for a general purpose parallel programming language. Examples show that such a language can accept real-time external inputs and outputs, and mimic assignment ...
Cleary, John G.   +2 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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