Results 81 to 90 of about 1,879,885 (315)
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Logic Column 18: Alternative Logics: A Book Review [PDF]
arXiv, 2007 This article discusses two books on the topic of alternative logics in science: "Deviant Logic", by Susan Haack, and "Alternative Logics: Do Sciences Need Them?", edited by Paul Weingartner.
arxiv
Teaching Database Security in an Undergraduate Database Administration Course Serving Computer Science, Information Technology and Cybersecurity Students [PDF]
, 2022 Mir Hasan +2 more
openalex +1 more source
Secure object-oriented databases [PDF]
, 2014 D.Phil. (Computer Science)The need for security in a database is obvious. Object-orientation enables databases to be used in applications where other database models are not adequate.
Olivier, Martin Stephanus
core +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Development of Computer Science Disciplines - A Social Network Analysis Approach [PDF]
arXiv, 2011 In contrast to many other scientific disciplines, computer science considers conference publications. Conferences have the advantage of providing fast publication of papers and of bringing researchers together to present and discuss the paper with peers.
arxiv
On the automated extraction of regression knowledge from databases [PDF]
, 1993 The advent of inexpensive, powerful computing systems, together with the increasing amount of available data, conforms one of the greatest challenges for next-century information science.
Muruzábal, Jorge
core +1 more source