Results 81 to 90 of about 26,107,313 (262)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A persistent view of encapsulation [PDF]
, 2011 This work was supported by EPSRC Grants GR/J67611 “Delivering the Benefits of Persistence” and GR/L32699 “Compliant Systems Architecture”, and the ESPRIT Working Group EP22552 “PASTEL”.Orthogonal persistence ensures that information will exist for as ...
Morrison, Ronald +1 more
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Proceedings ICACSIS 2014 (International Conference on Advanced Computer Science and Information System): October 18th and 19th 2014, Ambhara Hotel Blok M, Jakarta, Indonesia [PDF]
, 2014 Jakartaxxii, 520 p.: bibl.
Fac. of Computer Science, Universitas Indonesia
core
ChatGPT in Computer Science Education: A Case Study on a Database Administration Course
Applied SciencesGenAI tools like ChatGPT have changed the educational landscape, and empirical experiences are needed to better understand how to use them to their fullest potential. This article empirically explores the usage of ChatGPT 3.5 in database administration education through a case study conducted with 40 computer science students. Specifically, it inspects
López Fernández, Daniel +1 more
openaire +4 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Finding Computer Science Syllabi on the World Wide Web [PDF]
, 2006 Syllabi contain information useful to students, faculty, and many other people, and given the ubiquity of the WWW many schools are now putting their syllabi online for these people and the general public to access.
Fox, Edward A. +2 more
core +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Proceedings ICACSIS 2013 (International Conference on Advanced Computer Science and Information System): September 28th - 29th 2013, Sanur Paradise Plaza Hotel, Bali, Indonesia [PDF]
, 2013 Jakartaxvi, 461 p.: bibl.
Fac. of Computer Science, Universitas Indonesia
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source