Results 91 to 100 of about 498,375 (267)
Parallel Load Balancing Strategies for Ensembles of Stochastic Biochemical Simulations
, 2010 The evolution of biochemical systems where some chemical species are present with only a small number of molecules, is strongly influenced by discrete and stochastic effects that cannot be accurately captured by continuous and deterministic models.
Ahn, Tae-Hyuk +5 more
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Modeling cache performance beyond LRU
, 2016 Modern processors use high-performance cache replacement policies that outperform traditional alternatives like least-recently used (LRU). Unfortunately, current cache models do not capture these high-performance policies as most use stack distances ...
Nathan Beckmann +3 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Using Latency to Evaluate Computer System Performance
, 2014 Building high performance computer systems requires an understanding of the behaviour of systems and what makes them fast or slow. In addition to our file system performance analysis, we have a number of projects in measuring, evaluating, and ...
Mgbole F., Olawuyi J.O
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Accelerating Workloads on FPGAs via OpenCL: A Case Study with OpenDwarfs
, 2016 For decades, the streaming architecture of FPGAs has delivered accelerated performance across many application domains, such as option pricing solvers in finance, computational fluid dynamics in oil and gas, and packet processing in network routers and ...
Krommydas, Konstantinos +3 more
core
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
, 2011 While it has been suggested that immersive virtual environments could provide benefits for educational applications, few studies have formally evaluated how the enhanced perceptual displays of such systems might improve learning.
Bowman, Douglas A. +2 more
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source