Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Correction: Kim et al. Multi-Threaded Sound Propagation Algorithm to Improve Performance on Mobile Devices. <i>Sensors</i> 2023, <i>23</i>, 973. [PDF]
Sensors (Basel)Kim E, Choi S, Kim CG, Park WC.
europepmc +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Load-Varying LINPACK: A Benchmark for Evaluating Energy Efficiency in High-End Computing
, 2010 For decades, performance has driven the high-end computing (HEC) community. However, as highlighted in recent exascale studies that chart a path from petascale to exascale computing, power consumption is fast becoming the major design constraint in HEC ...
Feng, Wu-chun, Subramaniam, Balaji
core
Correction: Detection of DSCP-based traffic prioritization manipulations and their impact on network performance. [PDF]
Sci RepRahman MMH, Alnaeem M, Ibrahim AA.
europepmc +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Mitigating bias in multilabel medical text classification: a cooperative training framework with dynamic debiasing. [PDF]
BioinformaticsLi P, Zhang X, Hu X, Lin Z, Zhou D.
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
MOANA: Modeling and Analyzing I/O Variability in Parallel System Experimental Design
, 2018 Exponential increases in complexity and scale make variability a growing threat to sustaining HPC performance at exascale. Performance variability in HPC I/O is common, acute, and formidable. We take the first step towards comprehensively studying linear
Xu, Li +9 more
core
Correction: Irshad et al. A Novel IoT-Enabled Healthcare Monitoring Framework and Improved Grey Wolf Optimization Algorithm-Based Deep Convolution Neural Network Model for Early Diagnosis of Lung Cancer. <i>Sensors</i> 2023, <i>23</i>, 2932. [PDF]
Sensors (Basel)Irshad RR +8 more
europepmc +1 more source