Results 101 to 110 of about 498,375 (267)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Computer system dependability : an introduction [PDF]
More reliance is being placed on computer systems in many applications. Such systems need to be dependable; we must be able to depend on them to provide the required level of service without failure.
Lord, Andrew M.
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Comput. Sci. J. Moldova, 2008 Evolution of the informatization notion (which assumes automation of majority of human activities applying computers, computer networks, information technologies) towards the notion of {\it Global Information Society} (GIS) challenges the determination of new paradigms of society: automation and intellectualization of production, new level of education
Artiom Alhazov +9 more
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Architecture-Aware Optimization on a 1600-core Graphics Processor
, 2011 The graphics processing unit (GPU) continues to make significant strides as an accelerator in commodity cluster computing for high-performance computing (HPC).
Feng, Wu-chun +2 more
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FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
, 2009 This paper presents a novel parallelization and quantitative characterization of various optimization strategies for data-parallel computation on a graphics processing unit (GPU) using NVIDIA's new GPU programming framework, Compute Unified Device ...
Ponce, Sean +5 more
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Exploring the Impact of Context Sensitivity on Blended Analysis
, 2010 This paper explores the use of context sensitivity both intra- and interprocedurally in a blended (static/dynamic) program analysis for performance diagnosis of framework-intensive Web-based applications.
Ryder, Barbara G. +3 more
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