Results 61 to 70 of about 78,623 (223)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Trailblazing through a Knowledge Space of Science: Forward Citation Expansion in CiteSeer [PDF]

open access: yes, 2006
Understanding emerging trends and patterns in science and technology is essential not only to scientists and engineers in their own fast-advancing fields but also to a wide variety of individuals and organizations who are also interested in tracking the ...
Chen, Chaomei, Lin, Xia, Zhu, Weizhong
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Social scientists at work on the electronic network [PDF]

open access: yes, 1992
The purpose of this article is to contribute to our stock of knowledge about who uses networks, how they are used, and what contribution the networks make to advancing the scientific enterprise.
Robbin, Alice
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Supporting Meaningful Social Networks

open access: yes
Recent years have seen exponential growth of social network sites (SNSs) such as Friendster, MySpace and Facebook. SNSs flatten the real-world social network by making personal information and social structure visible to users outside the ego-centric ...
Huang, Yongjian
core  

On characterizing sectoral interactions via connections between employees in professional online social networks

open access: yes, 2018
The collaboration among individuals is essential to maximize economic efficiency. Today most of the technological and economical advancements require multidisciplinary efforts.
Ayvaz, Demet   +2 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

A New Centrality Measure for Social Network Analysis Applicable to Bibliometric and Webometric Data

open access: yes, 2006
In the literature there are a large number of publications in sociology, in computer science or in information sciences, as well as in studies of collaboration in science describing the studies of social networks with unweighted ties because measures ...
Theo Kretschmer   +3 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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