Results 11 to 20 of about 1,361,155 (249)
Computational Science and Engineering - Research Software Engineering Workflow : Research Report
, 2022 A minimal example of a research report (internal technical report, article preprint, manuscript submitted to peer-review), cross-linked with research data, code archive and repository, as a part of the Research Software Engineering (RSE) workflow for Computational Science and Engineering.
Maric, Tomislav, TU Darmstadt
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A Research Software Engineering Workflow for Computational Science and Engineering
, 2022 University research groups in Computational Science and Engineering (CSE) generally lack dedicated funding and personnel for Research Software Engineering (RSE), which, combined with the pressure to maximize the number of scientific publications, shifts the focus away from sustainable research software development and reproducible results.
Maric, Tomislav +6 more
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Software Engineering, Computer Engineering, Computer Science: Sibling Disciplines with Diverse Cultures [PDF]
2011 ASEE Annual Conference & Exposition Proceedings, 2020 Software Engineering, Computer Engineering, Computer Science Sibling Disciplines with Diverse CulturesEvery program of study has an institutional context and it has roots in an intellectual culture thatinforms its character. Its institutional context influences its content, its relationships with otherprograms, and the character of the graduates, among
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Mathematics, Computer Science, Software Engineering
Electronic Notes in Theoretical Computer Science, 2001 AbstractIn this talk I want to examine three ideas: First, the traditional relationship between a science, the mathematics it uses, and the engineering for which it is the basis. Second, the role of mathematics in the practice of software engineering, which is sometimes called “formal methods.” And finally, the role of theory in computer science, and ...
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
LGBTQIA+ (In) Visibility in Computer Science and Software Engineering Education
2023 IEEE/ACM 16th International Conference on Cooperative and Human Aspects of Software Engineering (CHASE), 2023 Modern society is diverse, multicultural, and multifaceted. Because of these characteristics, we are currently observing an increase in the debates about equity, diversity, and inclusion in different areas, especially because several groups of individuals are underrepresented in many environments.
Santos, Ronnie de Souza +2 more
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source