Results 91 to 100 of about 2,886,954 (299)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Protocol to perform integrative analysis of high-dimensional single-cell multimodal data using an interpretable deep learning technique

STAR Protocols
Summary: The advent of single-cell multi-omics sequencing technology makes it possible for researchers to leverage multiple modalities for individual cells.
Manqi Zhou, Hao Zhang, Zilong Bai, Dylan Mann-Krzisnik, Fei Wang, Yue Li   +5 more
doaj   +1 more source

Decision Making: A Computer-Science and Information-Technology Viewpoint [PDF]

We address the phenomenon of decision making from the viewpoint of computer science and information technology. The basic question from this viewpoint is: what can the computer offer to decision makers and how it can support their work?
Marko Bohanec
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Computational protocol for modeling and analyzing synaptic dynamics using SRPlasticity

STAR Protocols
Summary: Transient changes in synaptic strength, known as short-term plasticity (STP), play a fundamental role in neuronal communication. Here, we present a protocol for using SRPlasticity, a software package that implements a computational model of STP.
Jade Poirier, John Beninger, Richard Naud   +2 more
doaj   +1 more source

Computer science: Virtually there [PDF]

Nature, 2012
John Gilbey applauds a call for the digital to join the physical, biological and social in science.
openaire   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Generative AI and Disinformation| Unveiling Disinformation Narratives With AI: Collaborative Insights from Fact-Checkers and Computer Scientists’ Work in Analyzing Climate Misinformation Narratives

International Journal of Communication
Fact-checkers are shifting from debunking isolated falsehoods to analyzing broader disinformation narratives, aiming to uncover common themes and underlying messages within these pieces of misinformation.
Irene Larraz, Ramón Salaverría, Javier Serrano-Puche   +2 more
doaj  

Informatização da produção e qualidade total Computerization of operations and total quality

Estudos de Sociologia, 2007
O ensaio analisa o processo de requalificação da força de trabalho demandado pela introdução das novas tecnologias da informação no interior do processo produtivo, tomando como objeto os <i>Programas de Qualidade Total</i>. Considerando que a
Simone Wolff
doaj  

Computational reproducibility in computational social science

EPJ Data Science
AbstractOpen science practices have been widely discussed and have been implemented with varying success in different disciplines. We argue that computational-x disciplines such as computational social science, are also susceptible to the symptoms of the crises, but in terms of reproducibility.
Schoch, David, Chan, Chung-hong, Wagner, Claudia, Bleier, Arnim   +3 more
openaire   +4 more sources