Results 111 to 120 of about 2,886,954 (299)

Linking of the BENSON graph-plotter with the Elektronika-1001 computer [PDF]

A device, developed by the Institute of Space Research of the Academy of Sciences of the USSR, for linking the Elektronika-100I computer with the BENSON graph-plotter is described.
Nilolaev, N. Y., Popov, M. V., Soglasnov, V. A., Valtts, I. Y.   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Protocol to build open-source Discrimin8 maze to study discrimination of reward-context associations in mice during open-field foraging

STAR Protocols
Summary: The hippocampus is known to process context-specific memories. We provide a protocol for studying context discrimination in mice utilizing the open-source Discrimin8 maze.
Gergely Tarcsay, Laura A. Ewell
doaj   +1 more source

Small business innovation research. Abstracts of 1988 phase 1 awards [PDF]

Non-proprietary proposal abstracts of Phase 1 Small Business Innovation Research (SBIR) projects supported by NASA are presented. Projects in the fields of aeronautical propulsion, aerodynamics, acoustics, aircraft systems, materials and structures ...

core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Protocol for assessing neighborhood physical disorder using the YOLOv8 deep learning model

STAR Protocols
Summary: Neighborhood physical disorder (PD), characterized by disruptions and irregularities in spatial elements, is associated with negative economic, social, and public health outcomes. Here, we present a protocol to quantitatively assess PD utilizing
Yan Li, Yue Ma, Ying Long
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Protocol for making forecasts exogenous in the International Futures model

STAR Protocols
Summary: Understanding future dynamics and trends in human and natural development is foundational for creating appropriate policy strategies to address planetary and development challenges. Here, we present a protocol for adding exogenous series for key
José Solórzano, Barry B. Hughes, Mohammod T. Irfan, Yutang Xiong, Stellah Kwasi, Abdelrahman Ibrahim, Solikhakhon Makhmatova, Taylor Hanna, Jonathan D. Moyer   +8 more
doaj   +1 more source