Results 81 to 90 of about 1,449,054 (317)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Protocol for estimating the impact of climate change on economic growth and inequality under climate policies

open access: yesSTAR Protocols, 2023
Summary: The impact of climate change on economic inequality has attracted increasing attention from both government and academia. Here, we present a protocol for estimating both the impact of climate change on economic growth and economic growth ...
Yun Tang, Hongbo Duan, Shi-Yun Yu
doaj  

Maps of Computer Science

open access: yes2014 IEEE Pacific Visualization Symposium, 2014
10 pages, 8 figures, live version and source code available at mocs.cs.arizona ...
Stephen G. Kobourov, Daniel Fried
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Using Quantum Computers to Learn Physics [PDF]

open access: yesarXiv, 2014
Since its inception at the beginning of the twentieth century, quantum mechanics has challenged our conceptions of how the universe ought to work; however, the equations of quantum mechanics can be too computationally difficult to solve using existing computers for even modestly large systems.
arxiv  

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Protocol for designing, optimizing, and analyzing reverse supply chains using RELOG

open access: yesSTAR Protocols, 2023
Summary: In this protocol, we describe the use of RELOG, an open-source, supply chain optimization package, for robust design and analysis of optimal reverse logistics and manufacturing networks.
Chukwunwike O. Iloeje   +4 more
doaj  

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