Results 111 to 120 of about 7,984,444 (369)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Software for Quantum Computation

open access: yes, 2019
Some computational tasks, such as solving the discrete logarithm problem, can be computed with exponential better scaling on quantum computers than using classical hardware. Due to these algorithms, a digital quantum computer is strongly sought after. A scalable quantum computer needs fault-tolerant protocols to correct for errors and deviations due ...
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Bi-DNE: bilayer evolutionary pattern preserved embedding for dynamic networks

open access: yesComplex & Intelligent Systems
Network embedding is a technique used to generate low-dimensional vectors representing each node in a network while maintaining the original topology and properties of the network.
Xu Gu   +4 more
doaj   +1 more source

Review of Informing the Future of the Past: Guidelines for Historic Environment Records 2nd edition (website)

open access: yesInternet Archaeology, 2007
Informing the Future of the Past: Guidelines for Historic Environment Records (second) edition is billed as the 'New and improved manual that empowers HER managers to realise the full potential of their records as information systems for the historic ...
Ben Robinson
doaj   +1 more source

Validation of computer software to estimate dietary intake among patients with type 2 diabetes. [PDF]

open access: yesJ Clin Biochem Nutr, 2021
Wada S   +11 more
europepmc   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Non rivalry and complementarity in computer software [PDF]

open access: yes
In this paper we contend that – contrary to what argued by a vast part of the literature – computer software and, more in general, digital goods (i.e. symbolic strings on an electronic medium with some eco- nomic value) do not present the characteristics
Marengo, Luigi, Pasquali, Corrado
core   +1 more source

Development of a Collaborative Design Tool for Structural Analysis in an Immersive Virtual Environment [PDF]

open access: yes, 2001
This paper contains the results of an on-going collaborative research effort by the departments of Architecture and Computer Science of Virginia Polytechnic Institute and State University, U.S.A., to develop a computer visualization application for the ...
Bowman, Doug A., Setareh, M., Tumati, P.
core   +1 more source

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