Results 41 to 50 of about 3,363,328 (269)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Memory-augment graph transformer based unsupervised detection model for identifying performance anomalies in highly-dynamic cloud environments

Journal of Cloud Computing: Advances, Systems and Applications
Cloud computing systems provide highly available and scalable computing, storage, and network resources to meet various service demands. Anomaly detection based on monitoring metrics plays a crucial role in identifying system defects and abnormal ...
Huangyining Gao, Ruyue Xin, Peng Chen, Xi Li, Ning Lu, Peng You   +5 more
doaj   +1 more source

CDF-LS: Contrastive Network for Emphasizing Feature Differences with Fusing Long- and Short-Term Interest Features

Applied Sciences, 2023
Modelling both long- and short-term user interests from historical data is crucial for generating accurate recommendations. However, unifying these metrics across multiple application domains can be challenging, and existing approaches often rely on ...
Kejian Liu, Wei Wang, Rongju Wang, Xuran Cui, Liying Zhang, Xianzhi Yuan, Xianyong Li   +6 more
doaj   +1 more source

Software for Wearable Devices: Challenges and Opportunities

, 2015
Wearable devices are a new form of mobile computer system that provides exclusive and user-personalized services. Wearable devices bring new issues and challenges to computer science and technology.
Chen, Xin, Jiang, He, Kong, Weiqiang, Zhang, Shuwei, Zhang, Tao, Zhang, Xin   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

AI–Augmented Real-Time Collaborative Blended Modeling Framework for Automotive Embedded Systems

IET Software
Model-driven engineering (MDE) has emerged as a foundational paradigm for the development of embedded systems in domains such as automotive, where stringent correctness and structural consistency must be maintained throughout the engineering process ...
Misbah Mehboob Awan, Muhammad Waseem Anwar, Wasi Haider Butt, Farooque Azam   +3 more
doaj   +1 more source

Task offloading in hybrid-decision-based multi-cloud computing network: a cooperative multi-agent deep reinforcement learning

Journal of Cloud Computing: Advances, Systems and Applications, 2022
Multi-cloud computing is becoming a promising paradigm to provide abundant computation resources for Internet-of-Things (IoT) devices. For a multi-device multi-cloud network, the real-time computing requirements, frequently varied wireless channel gains ...
Juan Chen, Peng Chen, Xianhua Niu, Zongling Wu, Ling Xiong, Canghong Shi   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Optimization of companies’ activity on development of electronic product

Nauka ta progres transportu, 2012
The article considers modern processes of informatization of activity for business companies. There are generalized the makes of world companies, which create information technologies in global information environment: the electronic information product ...
K.V. Nalivaychenko
doaj  

EmbeddedPigDet—Fast and Accurate Pig Detection for Embedded Board Implementations

Applied Sciences, 2020
Automated pig monitoring is an important issue in the surveillance environment of a pig farm. For a large-scale pig farm in particular, practical issues such as monitoring cost should be considered but such consideration based on low-cost embedded boards
Jihyun Seo, Hanse Ahn, Daewon Kim, Sungju Lee, Yongwha Chung, Daihee Park   +5 more
doaj   +1 more source