Results 61 to 70 of about 3,363,328 (269)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Vehicle detection in drone aerial views based on lightweight OSD-YOLOv10

Scientific Reports
To address the challenges of low performance in vehicle image detection from UAV aerial imagery, difficulties in small target feature extraction, and the large parameter size of existing models, we propose the OSD-YOLOv10 algorithm, an enhanced version ...
Yang Zhang, Xiaobing Chen, Su Sun, Hongfeng You, Yuanyuan Wang, Jianchu Lin, Jiacheng Wang   +6 more
doaj   +1 more source

Software development for flexible pavement thickness design based on aastho and road note 31 [PDF]

, 2009
Nowadays, road and surface failure has become a critical issue in our country on the flexible pavement which reflects to a bad quality and error during design stage.
Chang, Tun Hua
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Justification of the costs of forest reclamation of lands subject to desertification

Siberian Journal of Life Sciences and Agriculture
Background. In recent decades, environmental problems related to land degradation and depletion of soil cover have become especially acute in the south of Russia. The consequences of these threats are commonly referred to as desertification.
Evgenia A. Korneeva
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Robin Hood às avessas: software, pirataria e direito autoral

Revista Direito GV
Resumo Como a pirataria influencia o mercado de programas de computador? A presente pesquisa visa analisar os efeitos respectivos da pirataria tanto para as grandes corporações quanto para os pequenos desenvolvedores de software.
Marcos Vinício Chein Feres, Jordan Vinícius de Oliveira, Daniel Domingues Gonçalves   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A software control system for the ACTS high-burst-rate link evaluation terminal [PDF]

Control and performance monitoring of NASA's High Burst Rate Link Evaluation Terminal (HBR-LET) is accomplished by using several software control modules.
Daugherty, Elaine S., Reinhart, Richard C.   +1 more
core   +1 more source

Digital Palaeography [PDF]

, 2009
This article seeks to explore new digital ways of distinguishing between scribal hands in medieval manuscripts. An analysis of traditional palaeographical approaches to hand identification will be followed by a discussion in which attention will be paid ...
Aussems, Mark, Brink, Axel
core