Results 71 to 80 of about 3,565,684 (300)

Generating approximate ground states of strongly correlated quantum many-body systems through quantum imaginary time evolution

Journal of Physics Communications
Most quantum algorithms designed to generate or probe properties of the ground state of a quantum many-body system require as input an initial state with a large overlap with the desired ground state.
Michael Kaicher, Florian Dommert, Christopher Wever, Maximilian Amsler, Michael Kühn, QUTAC Material Science Working Group   +5 more
doaj   +1 more source

Hybrid QM/MM Car-Parrinello Simulations of Catalytic and Enzymatic Reactions

CHIMIA, 2002
First-principles molecular dynamics (Car-Parrinello) simulations based on density functional theory have emerged as a powerful tool for the study of physical, chemical and biological systems.
Maria Carola Colombo, Martin Zumstein, Joost VandeVondele, Marialore Sulpizi, Katrin Spiegel, Ute Röhrig, Stefano Piana, Patrick Maurer, Alessandra Magistrato, Alessandro Laio, Leonardo Guidoni, Ursula Röthlisberger   +11 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Computers and Legal Reasoning: Developments in Germany

, 2022
S.141-147The importance of ldquoreasoningrdquo in law is pointed out. Law and jurisprudence belong to the ldquoreasoning-consciousrdquo disciplines. Accordingly, there is a long tradition of logic in law.
Fiedler, H.
core   +1 more source

Circulating miRNA’s biomarkers for early detection of hepatocellular carcinoma in Egyptian patients based on machine learning algorithms

Scientific Reports
Liver cancer, which ranks sixth globally and third in cancer-related deaths, is caused by chronic liver disorders and a variety of risk factors. Despite therapeutic improvements, the prognosis for Hepatocellular Carcinoma (HCC) remains poor, with a 5 ...
Gehad Ismail Sayed, Mona Solyman, Gamalat El Gedawy, Yasmine S. Moemen, Hassan Aboul-Ella, Aboul Ella Hassanien   +5 more
doaj   +1 more source

Biosensors with Built-In Biomolecular Logic Gates for Practical Applications

Biosensors, 2014
Molecular logic gates, designs constructed with biological and chemical molecules, have emerged as an alternative computing approach to silicon-based logic operations. These molecular computers are capable of receiving and integrating multiple stimuli of
Yu-Hsuan Lai, Sin-Cih Sun, Min-Chieh Chuang   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Computers & Culture, Issue 2

, 2023
Computers & Culture is an interdisciplinary digital pamphlet featuring short essays and notes of relevance to the digital and computers in the wider arts, humanities, and social sciences.
Andrews, Jim, Constantinou, Stace, Ní Loingsigh, Katie   +2 more
core  

Disorder and Motion in Crystal Structures: Nuisance and Opportunities

CHIMIA, 2001
Conventional structure analysis averages the structure of an entire crystal into a single unit cell. If there is disorder and thermal motion, this averaging obscures information on local structure, intermolecular interactions and molecular ...
Hans-Beat Bürgi, Thomas Weber
doaj  

Transcriptomic meta-analysis to identify potential antifungal targets in Candida albicans

BMC Microbiology
Background Candida albicans is a fungal pathogen causing human infections. Here we investigated differential gene expression patterns and functional enrichment in C. albicans strains grown under different conditions.
Zeinab Abdelmoghis Hefny, Boyang Ji, Ibrahim E. Elsemman, Jens Nielsen, Patrick Van Dijck   +4 more
doaj   +1 more source