Results 91 to 100 of about 3,565,684 (300)
Are Computers Good for Children? The Effects of Home Computers on Educational Outcomes [PDF]
Although computers are universal in the classroom, nearly twenty million children in the United States do not have computers in their homes. Surprisingly, only a few previous studies explore the role of home computers in the educational process.
Daniel O. Beltran +2 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Apples & oranges? Comparing unconventional computers
, 2010 Complexity theorists routinely compare—via the pre-ordering induced by asymptotic notation—the efficiency of computers so as to ascertain which offers the most efficient solution to a given problem. Tacit in this statement, however, is that the computers
Blakey, Ed
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, 2023 Computers & Culture is an interdisciplinary digital pamphlet featuring short essays and notes of relevance to the digital and computers in the wider arts, humanities, and social sciences.
MacCarron, Máirín +4 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
, 2023 Computers & Culture is an interdisciplinary digital pamphlet featuring short essays and notes of relevance to the digital and computers in the wider arts, humanities, and social sciences.
Andrews, Jim +2 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2005 The interdisciplinary research monograph, which has been peer-reviewed by several international experts assigned by Elsevier, introduces ground breaking original results in formal paradigms, architectures and laboratory implementations of computers based
Asai, Tetsuya +5 more
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Enhancing the electron pair approximation with measurements on trapped-ion quantum computers
npj Quantum InformationThe electron pair approximation offers an efficient variational quantum eigensolver (VQE) approach for chemistry simulations on quantum computers. With the number of entangling gates scaling quadratically with system size and a constant measurement ...
Luning Zhao +7 more
doaj +1 more source