Results 91 to 100 of about 33,828 (297)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Multiplicity of solutions to a p-Kirchhoff equation with critical exponent

Boundary Value Problems
In this paper, we consider the following p-Kirchhoff equation: P { [ M ( ∥ u ∥ p ) ] p − 1 ( − Δ p u + | u | p − 2 u ) = λ f ( x , u ) + | u | p ∗ − 2 u in Ω , u = 0 , on ∂ Ω , $$ \left \{ \textstyle\begin{array}{l@{\quad}l} [M(\|u\|^{p})]^{p-1}\left ...
Zhaomin Jiang
doaj   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Existence for (p, q) critical systems in the Heisenberg group

Advances in Nonlinear Analysis, 2019
This paper deals with the existence of entire nontrivial solutions for critical quasilinear systems (𝓢) in the Heisenberg group ℍn, driven by general (p, q) elliptic operators of Marcellini types.
Pucci Patrizia, Temperini Letizia
doaj   +1 more source

Multiplicity of solutions for quasilinear elliptic problems involving $\Phi$-Laplacian operator and critical growth

Electronic Journal of Qualitative Theory of Differential Equations, 2019
In this paper, we study a class of quasilinear elliptic equations with $\Phi$-Laplacian operator and critical growth. Using the symmetric mountain pass theorem and the concentration-compactness principle, we demonstrate that there exists $\lambda_i>0 ...
Xuewei Li, Gao Jia
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Existence of positive solutions to Kirchhoff type problems involving singular and critical nonlinearities

Electronic Journal of Differential Equations, 2018
In this study, we study a Kirchhoff type problem involving singular and critical nonlinearities. With aid of variational methods and concentration compactness principle, we prove that the problem admits a weak solution.
Chun-Yu Lei, Gao-Sheng Liu
doaj  

Existence of multiple solutions for a quasilinear Neumann problem with critical exponent

Boundary Value Problems, 2018
The main purpose of this paper is to establish the existence and multiplicity of nontrivial solutions for a quasilinear Neumann problem with critical exponent.
Yuanxiao Li, Suxia Xia
doaj   +1 more source

The Liouville Equation with Singular Data: A Concentration-Compactness Principle via a Local Representation Formula

Journal of Differential Equations, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
BARTOLUCCI, DANIELE, TARANTELLO, GABRIELLA   +1 more
openaire   +2 more sources