Results 71 to 80 of about 33,308 (294)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Existence of ground state for fractional Kirchhoff equation with L 2 $L^{2}$ critical exponents

open access: yesBoundary Value Problems, 2020
In this paper, we consider a class of fractional Kirchhoff equations with L 2 $L^{2}$ critical exponents. By using the scaling technique and concentration-compactness principle we obtain the existence and nonexistence of ground state for fractional ...
Yaling Han, Yimin Zhang
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Ground state solutions for a class of Schrödinger–Poisson–Slater equation with Coulomb–Sobolev critical exponent

open access: yesBoundary Value Problems
This paper is concerned with the Schrödinger–Poisson–Slater equation involving the Coulomb–Sobolev exponent. We apply the concentration compactness principle and the Pohožaev-type identity to overcome loss of compactness caused by the Coulomb exponent ...
Jingai Du, Pengfei He, Hongmin Suo
doaj   +1 more source

Solutions for the quasi-linear elliptic problems involving the critical Sobolev exponent

open access: yesJournal of Inequalities and Applications, 2017
In this article, we study the existence and multiplicity of positive solutions for the quasi-linear elliptic problems involving critical Sobolev exponent and a Hardy term.
Yanbin Sang, Siman Guo
doaj   +1 more source

Existence and stability of solitons for the nonlinear Schr\"odinger equation on hyperbolic space

open access: yes, 2014
We study the existence and stability of ground state solutions or solitons to a nonlinear stationary equation on hyperbolic space. The method of concentration compactness applies and shows that the results correlate strongly to those of Euclidean space ...
Berestycki H   +6 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Existence and multiplicity of solutions for fractional Schödinger equation involving a critical nonlinearity

open access: yesAdvances in Difference Equations, 2019
In this paper, we investigate the fractional Schödinger equation involving a critical growth. By using the principle of concentration compactness and the variational method, we obtain some new existence results for the above equation, which improve the ...
Yongzhen Yun, Tianqing An, Guoju Ye
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

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