Results 71 to 80 of about 32,890 (279)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Existence for (p, q) critical systems in the Heisenberg group

open access: yesAdvances in Nonlinear Analysis, 2019
This paper deals with the existence of entire nontrivial solutions for critical quasilinear systems (𝓢) in the Heisenberg group ℍn, driven by general (p, q) elliptic operators of Marcellini types.
Pucci Patrizia, Temperini Letizia
doaj   +1 more source

Normalized solutions for critical Schrödinger equations involving (2,q)-Laplacian [PDF]

open access: yesOpuscula Mathematica
In this paper, we consider the following critical Schrödinger equation involving \((2,q)\)-Laplacian: \[\begin{cases} -\Delta u-\Delta_{q} u=\lambda u+\mu |u|^{\gamma-2}u+|u|^{2^*-2}u \quad\text{in }\mathbb{R}^N, \\ \int_{\mathbb{R}^N} |u|^{2}dx=a^2,\end{
Lulu Wei, Yueqiang Song
doaj   +1 more source

Exam‐level analysis of lecture capture viewing and student exam performance

open access: yesFEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Existence of multiple solutions for a quasilinear Neumann problem with critical exponent

open access: yesBoundary Value Problems, 2018
The main purpose of this paper is to establish the existence and multiplicity of nontrivial solutions for a quasilinear Neumann problem with critical exponent.
Yuanxiao Li, Suxia Xia
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Multiplicity of solutions to a p-Kirchhoff equation with critical exponent

open access: yesBoundary Value Problems
In this paper, we consider the following p-Kirchhoff equation: P { [ M ( ∥ u ∥ p ) ] p − 1 ( − Δ p u + | u | p − 2 u ) = λ f ( x , u ) + | u | p ∗ − 2 u in Ω , u = 0 , on ∂ Ω , $$ \left \{ \textstyle\begin{array}{l@{\quad}l} [M(\|u\|^{p})]^{p-1}\left ...
Zhaomin Jiang
doaj   +1 more source

Multiplicity of solutions for quasilinear elliptic problems involving $\Phi$-Laplacian operator and critical growth

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2019
In this paper, we study a class of quasilinear elliptic equations with $\Phi$-Laplacian operator and critical growth. Using the symmetric mountain pass theorem and the concentration-compactness principle, we demonstrate that there exists $\lambda_i>0 ...
Xuewei Li, Gao Jia
doaj   +1 more source

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