Results 71 to 80 of about 106,796 (274)

A variational study of some hadron bag models

, 2013
Quantum chromodynamics (QCD) is the theory of strong interaction and accounts for the internal structure of hadrons. Physicists introduced phe- nomenological models such as the M.I.T.
Treust, Loïc Le
core   +2 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Multiple solutions for a quasilinear Schrödinger system of Kirchhoff type with critical exponents

Boletim da Sociedade Paranaense de Matemática, 2019
This paper is devoted to the existence of solutions for a class of Kirchhoff type systems involving critical exponents. The proof of the main results is based on  concentration compactness principle related to critical elliptic systems due to Kang ...
Mohammed Massar, Ahmed Hamydy, Najib Tsouli   +2 more
doaj   +1 more source

On the fractional Schr\"{o}dinger-Kirchhoff equations with electromagnetic fields and critical nonlinearity

, 2018
We consider the fractional Schr\"{o}dinger-Kirchhoff equations with electromagnetic fields and critical nonlinearity $\varepsilon^{2s}M([u]_{s,A_\varepsilon}^2)(-\Delta)_{A_\varepsilon}^su + V(x)u =$ $|u|^{2_s^\ast-2}u + h(x,|u|^2)u,$ $\ \ x\in \mathbb{R}
Liang, Sihua, Repovš, Dušan, Zhang, Binlin   +2 more
core   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Solutions for the quasi-linear elliptic problems involving the critical Sobolev exponent

Journal of Inequalities and Applications, 2017
In this article, we study the existence and multiplicity of positive solutions for the quasi-linear elliptic problems involving critical Sobolev exponent and a Hardy term.
Yanbin Sang, Siman Guo
doaj   +1 more source

Existence of ground state for fractional Kirchhoff equation with L 2 $L^{2}$ critical exponents

Boundary Value Problems, 2020
In this paper, we consider a class of fractional Kirchhoff equations with L 2 $L^{2}$ critical exponents. By using the scaling technique and concentration-compactness principle we obtain the existence and nonexistence of ground state for fractional ...
Yaling Han, Yimin Zhang
doaj   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Groundstates for a local nonlinear perturbation of the Choquard equations with lower critical exponent

, 2017
We prove the existence of ground state solutions by variational methods to the nonlinear Choquard equations with a nonlinear perturbation \[ -{\Delta}u+ u=\big(I_\alpha*|u|^{\frac{\alpha}{N}+1}\big)|u|^{\frac{\alpha}{N}-1}u+f(x,u)\qquad \text{ in ...
Van Schaftingen, Jean, Xia, Jiankang
core   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source