Results 71 to 80 of about 33,828 (297)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Existence of solutions to quasilinear elliptic systems with combined critical Sobolev-Hardy terms
Electronic Journal of Differential Equations, 2012 This article is devoted to the study of multiple positive solutions to a singular elliptic system where the nonlinearity involves a combination of concave and convex terms.
Nemat Nyamoradi, Mohamad Javidi
doaj
Remarks on the Moser-Trudinger inequality
, 2013 We extend the Moser-Trudinger inequality to any Euclidean domain satisfying Poincar\'e's inequality. We find out that the same equivalence does not hold in general for conformal metrics on the unit ball, showing counterexamples.
Battaglia, Luca, Mancini, Gabriele
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Multiple solutions of a p-Kirchhoff equation with singular and critical nonlinearities
Electronic Journal of Differential Equations, 2017 In this article, we explore the existence of multiple solutions for a p-Kirchhoff equation with the nonlinearity containing both singular and critical terms.
Qin Li, Zuodong Yang, Zhaosheng Feng
doaj
, 2013 We obtain an improved Sobolev inequality in H^s spaces involving Morrey norms. This refinement yields a direct proof of the existence of optimizers and the compactness up to symmetry of optimizing sequences for the usual Sobolev embedding. More generally,
Palatucci, Giampiero, Pisante, Adriano
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The concentration-compactness principle for fractional Orlicz-Sobolev spaces [PDF]
, 2023 Sabri Bahrouni, Olı́mpio H. Miyagaki
openalex +1 more source