Results 81 to 90 of about 32,890 (279)
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
Fractional elliptic problems with two critical Sobolev-Hardy exponents
Electronic Journal of Differential Equations, 2018 By using the mountain pass lemma and a concentration compactness principle, we obtain the existence of positive solutions to the fractional elliptic problem with two critical Hardy-Sobolev exponents at the origin.
Wenjing Chen
doaj
The concentration-compactness principle for variable exponent spaces and applications [PDF]
, 2022 Julián Fernández Bonder, Analía Silva
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DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Electronic Journal of Differential Equations, 2018 In this study, we study a Kirchhoff type problem involving singular and critical nonlinearities. With aid of variational methods and concentration compactness principle, we prove that the problem admits a weak solution.
Chun-Yu Lei, Gao-Sheng Liu
doaj
Nonlinear Analysis, 2018 In this paper, we consider the fractional Kirchhoff equations with electromagnetic fields and critical nonlinearity. By means of the concentration-compactness principle in fractional Sobolev space and the Kajikiya's new version of the symmetric mountain ...
Sihua Liang, Jihui Zhang
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang +16 more
wiley +1 more source
Boundary Value Problems, 2019 In this paper, we first obtain the existence of solutions for a class of elliptic equations involving critical variable exponents and nonlinear boundary values by the mountain pass theorem and concentration compactness principle.
Yingying Shan, Yongqiang Fu
doaj +1 more source
Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin +10 more
wiley +1 more source
Altered Dynamic Functional Network Connectivity in Post‐Stroke Aphasia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Previous studies examining post‐stroke aphasia (PSA) patients via resting‐state functional magnetic resonance imaging (rs‐fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients ...
Guihua Xu +6 more
wiley +1 more source