Results 31 to 40 of about 9,837,347 (345)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A three-dimensional finite element model of cAMP signals
Forces in Mechanics, 2021 This paper presents a three-dimensional finite element model for cyclic adenosine monophosphate (cAMP) signaling. Governing equations for the synthesis, diffusion, and degradation of cAMP were numerically implemented using the finite element method ...
R. Warren +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Cavalcade of Interpretations: The Kasztner train Through the Self-narratives of the Fugitives
Zagłada Żydów, 2023 The Kasztner train is one of the most well-known episodes of the Hungarian Holocaust. The action played a highly controversial role in the history of the Jewish self-rescue actions that elaborated in recent historiography.
Heléna Huhák, András Szécsényi
doaj +1 more source
, 2012 The Boer War, which is frequently referred to as Britain's Vietnam or Afghanistan, was marked by gross miscalculations on the part of both British military and political leaders.
J. R. Jewell
semanticscholar +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Archaeologia Polona, 2023 This article discusses the analysis of material discovered during archaeological excavations conducted in the areas of former concentration camps, based on the results of work carried out on the site of the former German concentration and extermination ...
Paweł Lewicki, Magdalena Mazurkiewicz
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Droit et justice pendant la Première Guerre mondiale. L’exemple de la France
Ler História, 2014 During the First World War, in France, as in other countries at war law went back in favor of exceptional procedures, getting to a point of exempt justice in the internment of civilian of enemy nationality and other undesirables.
Jean-Claude Farcy
doaj +1 more source