Results 41 to 50 of about 3,531,413 (264)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Solutions for the quasi-linear elliptic problems involving the critical Sobolev exponent

Journal of Inequalities and Applications, 2017
In this article, we study the existence and multiplicity of positive solutions for the quasi-linear elliptic problems involving critical Sobolev exponent and a Hardy term.
Yanbin Sang, Siman Guo
doaj   +1 more source

Existence of ground state for fractional Kirchhoff equation with L 2 $L^{2}$ critical exponents

Boundary Value Problems, 2020
In this paper, we consider a class of fractional Kirchhoff equations with L 2 $L^{2}$ critical exponents. By using the scaling technique and concentration-compactness principle we obtain the existence and nonexistence of ground state for fractional ...
Yaling Han, Yimin Zhang
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ground state solutions for a class of Schrödinger–Poisson–Slater equation with Coulomb–Sobolev critical exponent

Boundary Value Problems
This paper is concerned with the Schrödinger–Poisson–Slater equation involving the Coulomb–Sobolev exponent. We apply the concentration compactness principle and the Pohožaev-type identity to overcome loss of compactness caused by the Coulomb exponent ...
Jingai Du, Pengfei He, Hongmin Suo
doaj   +1 more source

Existence and multiplicity of solutions for fractional Schödinger equation involving a critical nonlinearity

Advances in Difference Equations, 2019
In this paper, we investigate the fractional Schödinger equation involving a critical growth. By using the principle of concentration compactness and the variational method, we obtain some new existence results for the above equation, which improve the ...
Yongzhen Yun, Tianqing An, Guoju Ye
doaj   +1 more source

A study and an application of the concentration compactness type principle

, 2019
In this article we develop a concentration compactness type principle in a variable exponent setup. As an application of this principle we discuss a problem involving fractional `{\it $(p(x),p^+)$-Laplacian}' and power nonlinearities with exponents $(p^+)^*$, $p_s^*(x)$ with the assumption that the critical set $\{x\inΩ:p_s^*(x)=(p^+)^*\}$ is nonempty.
Panda, Akasmika, Choudhuri, Debajyoti
openaire   +2 more sources