Results 61 to 70 of about 4,640 (267)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Multiple solutions of a p-Kirchhoff equation with singular and critical nonlinearities

Electronic Journal of Differential Equations, 2017
In this article, we explore the existence of multiple solutions for a p-Kirchhoff equation with the nonlinearity containing both singular and critical terms.
Qin Li, Zuodong Yang, Zhaosheng Feng
doaj  

Existence of positive ground state solutions of Schrödinger–Poisson system involving negative nonlocal term and critical exponent on bounded domain

Boundary Value Problems, 2019
In this paper, we prove the existence of positive ground state solutions of the Schrödinger–Poisson system involving a negative nonlocal term and critical exponent on a bounded domain.
Wenxuan Zheng, Wenbin Gan, Shibo Liu
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Existence of steady states for the Maxwell-Schrödinger-Poisson system: exploring the applicability of the concentration-compactness principle

, 2013
This paper is intended to review recent results and open problems concerning the existence of steady states to the Maxwell-Schrödinger system. A combination of tools, proofs and results are presented in the framework of the concentration--compactness ...
Dolbeault, Jean, Catto, Isabelle, Sánchez, Óscar, Soler, Juan   +3 more
core   +2 more sources

Doubly Critical Problems Involving Fractional Laplacians in ℝN

Advanced Nonlinear Studies, 2017
In this paper, we show the existence of nontrivial solutions for doubly critical nonlocal elliptic problems in ℝN{\mathbb{R}^{N}} involving fractional Laplacians.
Yang Jianfu, Wu Fengjie
doaj   +1 more source

The Compact Embeddings and the Concentration-Compactness Principles for Anisotropic Variable Exponent Sobolev Spaces and Applications

The Journal of Geometric Analysis
Abstract In this paper, we present new results about the compact embeddings of anisotropic variable exponent Sobolev spaces into variable Lebesgue spaces. We also refine and extend the concentration–compactness principle to trace embeddings in these spaces.
Nabil Chems Eddine, Maria Alessandra Ragusa   +1 more
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Uniform Concentration-Compactness for Sobolev Spaces on Variable Domains

, 2000
We present a new method for proving existence results in shape optimization problems involving the eigenvalues of the Dirichlet–Laplace operator. This method brings together the γ-convergence theory and the concentration-compactness principle.
Bucur, Dorin
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source