Results 131 to 140 of about 3,167,057 (258)

Is it time to recommend AUC-based vancomycin therapeutic drug monitoring only? A cross-sectional survey in China

open access: yesFrontiers in Pharmacology
BackgroundThe latest published therapeutic drug monitoring (TDM) guidelines for vancomycin recommend changing trough-based monitoring to area under the concentration-to-time curve (AUC)-based monitoring.
Jieqiong Liu   +14 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Curve and G-Spot at Christmas, 2009

open access: yes, 2009
A colour photograph of the Queen's Building, 37-43 Rutland Street, the G-Spot club and the new Curve theatre opposite. Built in 1897 and likely named for Queen Victoria’s diamond jubilee, the Queen's Building was Grade II listed in ...
Hyde, Colin;
core  

Reconciling wage curve and Phillips curve

open access: yes, 2005
The wage curve is the negative relationship that links wage levels to the unemployment rate. It fits accurately with modern non-competitive labour-market models, but goes against a Phillips-curve modelling, because the latter ties wage growth to the ...
Montuenga-Gómez, V.M.   +1 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Combating curve squeal noise

open access: yes, 2016
Society demand for more sustainable transports is increasing, starting a modal shift from road to railway. The resulting increase in railway traffic intensity is leading to more activities on the track, even during the night time.
Rantatalo, Matti,   +3 more
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Flat-of-the-Curve Medicine – A New Perspective on the Production of Health [PDF]

open access: yes
Health economists have studied the determinants of the expected value of health status as a function of medical and nonmedical inputs, often finding small marginal effects of the former.
Johannes Schoder, Peter Zweifel
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

POLA PERUBAHAN MONO DAN DIASILGLISEROL DALAM REAKSI ETANOLISIS MINYAK SAWIT MERAH [Change Pattern of Mono and Diacylglycerol in Ethanolysis Reaction of Crude Palm Oil]

open access: yesJurnal Teknologi dan Industri Pangan, 2003
The Changging Pattern of Mono and Diacylglycerol concentration as respon to Reaction time during ethanolysis of Crude Palm Oil was influenced by the ration of ethanol/CPO.
Asriani Hasanuddin   +2 more
doaj  

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