Results 91 to 100 of about 2,426,264 (355)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Exploring the Individual, Socioeconomic and Contextual Determinants Associated with Daily Tobacco Consumption in Portugal

open access: yesNotas Económicas
The National Program for Tobacco Prevention and Control reflects awareness of tobacco as a major public health problem in Portugal. To infer which population groups should be targeted, we estimate sex-specific logistic regressions to analyze the ...
Laura Almeida   +2 more
doaj   +1 more source

The concentration index of a binary outcome revisited

open access: yesHealth Economics, 2011
SUMMARYThe binary variable is one of the most common types of variables in the analysis of income‐related health inequalities. I argue that while the binary variable has some unusual properties, it shares many of the properties of the ratio–scale variable and hence lends itself to both relative and absolute inequality analyses, albeit with some ...
openaire   +3 more sources

Measuring income related inequality in health and health care: the partial concentration index with direct and indirect standardisation. [PDF]

open access: yes
The partial concentration index measures income related inequality in health (or health care) after removing the effects of standardising variables which affect health (or health care), are correlated with income but not amenable to policy.
Hugh Gravelle
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Measuring socioeconomic inequalities in postnatal health checks for newborns in Ethiopia: a decomposition analysis

open access: yesFrontiers in Public Health
BackgroundAddressing health inequity is a top priority for achieving sustainable development goals. The existing evidences in Ethiopia have shown that there are substantial inequalities in the use of health services among various socioeconomic strata ...
Asebe Hagos   +16 more
doaj   +1 more source

Agglomeration Index Towards a New Measure of Urban Concentration [PDF]

open access: yes
A common challenge in analyzing urbanization is the data. The United Nations (UN) compiles information on urbanization (urban population and its share of total national population) that is reported by various countries but there is no standardized ...
Nelson, Andrew, Uchida, Hirotsugu
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Exploring the spatial variation of intra-urban housing prices based on inverse S-function fitting of 35 cities

open access: yesFrontiers in Built Environment
Housing prices serve as a crucial indicator of macroeconomic stability and urban spatial vitality. However, existing studies on intra-urban housing prices predominantly focus on single-city empirical analyses or localized examinations of individual ...
Xiaojin Liang   +13 more
doaj   +1 more source

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