Results 91 to 100 of about 7,072,566 (293)

Socioeconomic inequity in extreme outcomes within very pre-term and/or very low birthweight infants: evidence from multi-national cohorts

Frontiers in Public Health
BackgroundPre-term birth (< 37 weeks' gestation) is a major cause of neonatal mortality, with very pre-term (< 32 weeks' gestation) and extremely pre-term (< 28 weeks' gestation) infants facing the highest risks.
Hanifa Pilvar, Catia Nicodemo, Catia Nicodemo, Stavros Petrou, Brian A. Darlow, Paula van Dommelen, Kari Anne I. Evensen, Sarah Harris, John Horwood, Samantha Johnson, Neil Marlow, Karen Mathewson, Saroj Saigal, Louis A. Schmidt, Dieter Wolke, Lianne J. Woodward, Sungwook Kim   +16 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Socioeconomic inequalities in teenage pregnancy in a fragile and politically unrecognized setting: evidence from the 2020 Somaliland demographic and health survey

International Journal of Adolescence and Youth
Teenage pregnancy remains a major global public health challenge with serious health and socioeconomic consequences for adolescent girls. Although widely studied worldwide, evidence from fragile and politically unrecognized settings remains limited ...
Eid Ibrahim Daud, Mona Mohamud Ahmed, Mushtaq Abdikarim Yousuf, Mahad Ibrahim Ali, Abdishakur Mohamed Hussein   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Global health inequities in retinoblastoma: a 1990–2021 analysis across socio-demographic index regions

Frontiers in Public Health
ObjectiveTo assess health inequities associated with retinoblastoma across various Socio-Demographic Index (SDI) regions and evaluate whether these inequities have decreased from 1990 to 2021, with the aim of enhancing awareness and guiding government ...
Xi Li, Ying Chang, Xiaoyu Zhao, Xi Liu, Ying Zhang, Xuan Wang, Junhong Li   +6 more
doaj   +1 more source

Dundee Discussion Papers in Economics 240:Longitudinal analysis of income-related health inequality: welfare foundations and alternative measures [PDF]

, 2010
This paper elaborates the approach to the longitudinal analysis of income-related health inequalities first proposed in Allanson, Gerdtham and Petrie (2010).
Allanson, Paul; id_orcid
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source