Results 211 to 220 of about 122,411 (287)

Real-Time Binding Kinetics of Membrane Protein-Protein Interactions in a Membraneless Setting. [PDF]

Anal Chem
Wang Y, Wu Y, Mayse LA, Capucilli D, Huang PJ, Ramachandran S, Luikham S, Ha JH, Loh SN, Wolfe AJ, Movileanu L.   +10 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Development of VP30-targeted nanoparticles using DPS4 fusion peptides for the inhibition of Ebola virus. [PDF]

J Nanobiotechnology
Wu F, Huang Y, Li R, Gao P, Lv P, Wu G, Ma Y, Ding Q, Zhong J, Su J, Xu W.   +10 more
europepmc   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Dual recombinase-mediated endothelial cell-specific lineage tracing and ablation. [PDF]

Cell Regen
Li J, Zhang M, Liu X, Zhang Z, Shi M, Pu W, Zhou B.   +6 more
europepmc   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain. [PDF]

Neurol Genet
Ghovanloo MR, Effraim PR, Tyagi S, Aldrich AM, Yuan JH, Schulman BR, Jacobs DS, Dib-Hajj SD, Waxman SG.   +8 more
europepmc   +1 more source

Challenges and Coping Strategies of Migrant Parents in Türkiye: A Qualitative Study

Child &Family Social Work, EarlyView.
ABSTRACT This qualitative study explored the coping mechanisms used by 22 immigrant parents (nine men, 13 women) of Syrian, Iraqi, Afghan and Palestinian origin in Türkiye to cope with challenges related to food, shelter, healthcare and social exclusion while caring for their children.
Murat Altuntaş, Habibullah Akinci
wiley   +1 more source

Bismuth Bicycles. [PDF]

J Pept Sci
Voss S, Sagar A, Tiberghien A, Hughes RJL, Chen L, Rioja I, Frigerio M, Skynner MJ, Spring DR.   +8 more
europepmc   +1 more source

Impact of Transnational Family Separation on Parenting and Psychosocial Well‐Being for Black African Migrant Parents in Hamilton

Child &Family Social Work, EarlyView.
ABSTRACT In light of increased migration from sub‐Saharan Africa (SSA) to Hamilton in the past 5 years, this qualitative study explores the experiences of Black African migrant parents resettling in Hamilton, Canada. Using semi‐structured interviews and thematic analysis, four key themes emerged: (1) impact of migration and family separation stress on ...
Tsinat Semagn, Ingrid Waldron, Allison Williams, Olive Wahoush   +3 more
wiley   +1 more source