Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Concept and Design Basic Training as an Information System in Support Program to Achieve Strategic Vision & Mission in Office of Public Accountants and Consultants Services [PDF]
The concept and basic design of the training information system is made as one ofstrategic programs to achieve the vision and mission of public accounting andconsulting services and / or organization that evaluates human resource developmentis a ...
Pangasto, A. (Ardian) +1 more
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
DESIGN CONCEPT - WARM INTERIOR SPACE [PDF]
Current housing development increased along with the human need for shelter. Nowadays residence is not only used by the owner directly, but also has shifted as a function of investment or leased to other parties.
Nyoman, Dewi Pebryani, S.T., M.A
core
The multiple meanings of the concept in the design: case study in design schools of Medellin [PDF]
This article focuses on how the design schools in Medellin have an epistemological approach of the term ‘concept’, which ultimately defines the teaching approaches they have when it comes to teaching the creative process ...
Carlos Mario Cano Ramírez
doaj +1 more source
Concept Design of AGV (Automated Guided Vehicle) Based on Image Detection and Positioning
Humanity is witnessing the fourth industrial revolution. In the fourth industrial revolution era, the high level of ICTs (Information and Communication Technologies) such as AI (Artificial Intelligence), IoT (Internet of Things), big data, cloud system ...
H. Cheong, Hwally Lee
semanticscholar +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Design concept for pressure switch calibrator [PDF]
Calibrator and switch design enables pressure switches to operate under 150 g shock loads. The design employs a saturated liquid-to-vapor phase transition at constant pressure to produce a known force independent of displacement over a usable ...
Slingerland, M. G.
core +1 more source
Development of concepts for a zero-fossil-energy greenhouse [PDF]
Dutch government and greenhouse horticultural practice aim for strongly reduced fossil energy use and of environmental loads in 2010 and energy neutral greenhouses in 2020.
Bot, G.P.A. +4 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

