Results 91 to 100 of about 4,803,411 (300)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Design concept for bolted Glass
Challenging Glass Conference Proceedings, 2010 For the design of load carrying glazing structures the connection technique plays an important role, as e.g. there are significant stress concentrations in the vicinity of holes that are subject to a point-like support of glass panes.
M. Baitinger, M. Feldmann
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
An analysis of design reuse benefits [PDF]
, 1998 Although the concept of design reuse is accepted as a valid approach to design, little attempt has been made to formalise the elements that constitutes design reuse. The few approaches formalising design reuse, e.g.
Duffy, A.H.B., Ferns, A. F.
core
The Metreleptin Effectiveness and Safety Registry (MEASuRE): concept, design and challenges. [PDF]
Orphanet J Rare Dis, 2023 Haymond MW +8 more
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Fuel element concept for long life high power nuclear reactors [PDF]
, 1969 Nuclear reactor fuel elements have burnups that are an order of magnitude higher than can currently be achieved by conventional design practice. Elements have greater time integrated power producing capacity per unit volume.
Mcdonald, G. E., Rom, F. E.
core +1 more source
Magnetohydrodynamic-based Internal Cooling System for a Ceramic Cutting Tool: Concept Design, Numerical Study, and Experimental Evalidation. [PDF]
Nanomanuf Metrol, 2023 O'Hara J, Fang F.
europepmc +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Design concept for the Flight Telerobotic Servicer (FITS) [PDF]
NASA has just completed an in-house Phase B Study (one of three studies) for the preliminary definition of a teleoperated robotic device that will be used on the National Space Transportation System (NSTS) and the Space Station to assist the astronauts ...
Andary, J. F. +2 more
core +1 more source